ArticleFrontiers in cardiovascular medicine2022
A tomographic microscopy-compatible Langendorff system for the dynamic structural characterization of the cardiac cycle.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Optimising 4D imaging of fast-oscillating structures using X-ray microtomography with retrospective gating.Scientific reports · 2024Article
- In Situ Loading and Time-Resolved Synchrotron-Based Phase Contrast Tomography for the Mechanical Investigation of Connective Knee Tissues: A Proof-of-Concept Study.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- History of the development of isolated heart perfusion experimental model and its pioneering role in understanding heart physiology.Archives of medical sciences. Atherosclerotic diseases · 2024Article
- Addressing Current Challenges in OSL Dosimetry Using MgBMaterials (Basel, Switzerland) · 2023Article
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Authors and funding
9 authors.
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Abstract
Introduction: Cardiac architecture has been extensively investigated Methods: This work presents the customization of an isolated, perfused heart system compatible with synchrotron-based X-ray phase contrast imaging (X-PCI). Results: Thanks to the capabilities of the developed setup, it was possible to visualize a beating isolated, perfused rat heart for the very first time in 4D at an unprecedented 2.75 μm pixel size (10.6 μm spatial resolution), and 1 ms temporal resolution. Discussion: The customized setup allows high-spatial resolution studies of heart architecture along the cardiac cycle and has thus the potential to serve as a tool for the characterization of the structural dynamics of the heart, including the effects of drugs and other substances able to modify the cardiac cycle.
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