Evidence map›Paper›PMID 36619992›Full record

ArticleFrontiers in microbiology2022

The CpxA/CpxR two-component system mediates regulation of

Qing Yao, Tingting Xie, Yu Fu, Jiajia Wan, Wendie Zhang, Xuejun Gao, Jing Huang, Diangang Sun, Fuxian Zhang, Weicheng Bei and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. The divergentMicrobiology (Reading, England) · 2026
    Article
  2. Plant-Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two-Component System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Evaluation of a multi-epitope vaccine PME forFrontiers in immunology · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Qing YaoCollege of Animal Sciences, Yangtze University, Jingzhou, Hubei, China.
Tingting XieCollege of Animal Sciences, Yangtze University, Jingzhou, Hubei, China.
Yu FuCollege of Animal Sciences, Yangtze University, Jingzhou, Hubei, China.
Jiajia WanCollege of Animal Sciences, Yangtze University, Jingzhou, Hubei, China.
Wendie ZhangCollege of Animal Sciences, Yangtze University, Jingzhou, Hubei, China.
Xuejun GaoCollege of Animal Sciences, Yangtze University, Jingzhou, Hubei, China.
Jing HuangSchool of Foreign Languages, Zhejiang Gongshang University, Hangzhou, Zhejiang, China.
Diangang SunCollege of Animal Sciences, Yangtze University, Jingzhou, Hubei, China.
Fuxian ZhangCollege of Animal Sciences, Yangtze University, Jingzhou, Hubei, China.
Weicheng BeiState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.
Liancheng LeiCollege of Animal Sciences, Yangtze University, Jingzhou, Hubei, China.
Feng LiuCollege of Animal Sciences, Yangtze University, Jingzhou, Hubei, China.
Yangtze University · CNHuazhong Agricultural University · CNJilin University · CNZhejiang Gongshang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: To survive in various hostile environments, two-component system is an adaptive mechanism for diverse bacteria. Activity of the CpxA/CpxR two-component system contributes to coping with different stimuli, such as pH, osmotic and heat stress. Methods: However, the role of the CpxA/CpxR system in cold resistance is little-known. In this study, we showed that CpxA/CpxRwas critical for Results: Discussion: These results presented in this study illustrated that the CpxA/CpxR system plays an important role in cold resistance by upregulating expression of

Indexed as

Actinobacillus pleuropneumoniaecold stressCpxA/CpxRcspCtwo-component system

Identifiers

PMID36619992
PMCPMC9816388
OpenAlexW4312176106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.