Evidence map›Paper›PMID 36619877›Full record

ArticleEngineering in life sciences2023

Application of an

Manh Dat Hoang, Dieu Thi Doan, Marlen Schmidt, Harald Kranz, Andreas Kremling, Anna-Lena Heins

Open access · goldAbstract read
In one paragraph

Article in Engineering in life sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Scale-down bioreactors-comparative analysis of configurations.Bioprocess and biosystems engineering · 2025
    Review
  2. Review
  3. Article
  4. Article
  5. Application of anEngineering in life sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Manh Dat HoangChair of Biochemical Engineering Department of Energy and Process Engineering TUM School of Engineering and Design Technical University of Munich Garching Germany.
Dieu Thi DoanSystems Biotechnology Department of Energy and Process Engineering TUM School of Engineering and Design Technical University of Munich Garching Germany.
Marlen SchmidtGen-H Genetic Engineering Heidelberg GmbH Heidelberg Germany.
Harald KranzGen-H Genetic Engineering Heidelberg GmbH Heidelberg Germany.
Andreas KremlingSystems Biotechnology Department of Energy and Process Engineering TUM School of Engineering and Design Technical University of Munich Garching Germany.
Anna-Lena HeinsChair of Biochemical Engineering Department of Energy and Process Engineering TUM School of Engineering and Design Technical University of Munich Garching Germany.
Technical University of Munich · DEHeidelberg Engineering (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biotechnological production processes are sustainable approaches for the production of biobased components such as amino acids for food and feed industry. Scale-up from ideal lab-scale bioreactors to large-scale processes is often accompanied by loss in productivity. This may be related to population heterogeneities of cells originating from isogenic cultures that arise due to dynamic non-ideal conditions in the bioreactor. To better understand this phenomenon, deeper insights into single-cell physiologies in bioprocesses are mandatory before scale-up. Here, a triple reporter strain (3RP) was developed by chromosomally integrating the fluorescent proteins mEmerald, CyOFP1, and mTagBFP2 into the L-phenylalanine producing

Indexed as

at‐line monitoringEscherichia colifluorescent reporter strainL‐phenylalaninepopulation heterogeneity

Identifiers

PMID36619877
PMCPMC9815085
OpenAlexW4214714747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.