Evidence map›Paper›PMID 36619865›Full record

ArticleFrontiers in cell and developmental biology2022

High-throughput

Veronica Valvo, Elena Parietti, Kyle Deans, Sebastian W Ahn, Noel Ruth Park, Benjamin Ferland, Devon Thompson, Christine Dominas, Sharath K Bhagavatula, Shawn Davidson and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
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  7. Review
  8. Glutaminolysis of CD4Journal of inflammation research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Veronica ValvoDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Elena PariettiDepartment of Infectious Diseases and Hospital of Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.
Kyle DeansDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Sebastian W AhnDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Noel Ruth ParkLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, United States.
Benjamin FerlandDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Devon ThompsonDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Christine DominasDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Sharath K BhagavatulaDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Shawn DavidsonLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, United States.
Oliver JonasDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Harvard University · USBrigham and Women's Hospital · USPrinceton University · USUniversity of Zurich · CH

Funding

Dynamic µOCT for cellular tissue phenotypingR01CA265742 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI JONAS, OLIVER, TEARNEY, GUILLERMO J · 2021 to 2025
$3.0M
A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosisR01DK117236 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI TEARNEY, GUILLERMO J, WOLFSEN, HERBERT · 2019 to 2022
$2.6M
Implantable microdevices with integrated optical imaging for high-throughput in situ tumor response and drug sensitivity measurementR37CA224144 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI JONAS, OLIVER · 2018 to 2023
$2.4M
In Situ characterization and manipulation of tumor immune cell metabolomics using implantable microdevicesR01CA223150 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI JONAS, OLIVER · 2018 to 2022
$1.9M
NCI NIH HHS R01 CA223150NCI NIH HHS R01 CA265742NCI NIH HHS R37 CA224144NIDDK NIH HHS R01 DK117236
6 · The paper itself

Abstract

Tumor-infiltrating immune cells experience significant metabolic reprogramming in the tumor microenvironment (TME), and they share similar metabolic pathways and nutrient needs with malignant cells. This positions these cell types in direct nutrient competition in the TME. We currently lack a complete understanding of the similarities, differences, and functional consequences of the metabolic pathways utilized by activated immune cells from different lineages

Indexed as

cancer metabolismimmunometabolismimmunotherapyin situ perturbationT-cells infiltrationtumor micro-environment

Identifiers

PMID36619865
PMCPMC9815512
OpenAlexW4312077707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.