Evidence map›Paper›PMID 36619767›Full record

ArticleFrontiers in cellular and infection microbiology2022

The antigen processing-associated transporter gene polymorphism: Role on gene and protein expression in HPV-infected pre-cancerous cervical lesion.

Fernanda Silva Medeiros, Mauro César da Silva, Neila Caroline Henrique da Silva, Thailany Thays Gomes, Renan Garcia Gomes, Larissa Albuquerque Paiva, Fabiana Oliveira Dos Santos Gomes, Christina Alves Peixoto, Maria Carolina Valença Rygaard, Stefan Welkovic and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Fernanda Silva MedeirosLaboratory of Immunogenetics, Department of Immunology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil.
Mauro César da SilvaLaboratory of Immunogenetics, Department of Immunology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil.
Neila Caroline Henrique da SilvaLaboratory of Immunogenetics, Department of Immunology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil.
Thailany Thays GomesLaboratory of Immunogenetics, Department of Immunology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil.
Renan Garcia GomesLaboratory of Molecular Biology, Institute of Integral Medicine Professor Fernando Figueira (IMIP) Hospital, Pediatric Oncology Service, Recife, Brazil.
Larissa Albuquerque PaivaGetúlio Vargas Hospital, Pernambuco Health Department, Recife, Brazil.
Fabiana Oliveira Dos Santos GomesLaboratory of Ultrastructure, Department of Entomology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil.
Christina Alves PeixotoLaboratory of Ultrastructure, Department of Entomology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil.
Maria Carolina Valença RygaardLaboratory of Molecular Biology, Institute of Integral Medicine Professor Fernando Figueira (IMIP) Hospital, Pediatric Oncology Service, Recife, Brazil.
Stefan WelkovicIntegrated Health Center Amaury de Medeiros (CISAM), University of Pernambuco, Recife, Brazil.
Maria Luiza Bezerra MenezesIntegrated Health Center Amaury de Medeiros (CISAM), University of Pernambuco, Recife, Brazil.
Eduardo Antônio DonadiClinical Immunology Division, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, Brazil.
Norma Lucena-SilvaLaboratory of Immunogenetics, Department of Immunology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil.
Fundação Oswaldo Cruz · BRInstituto de Medicina Integral Professor Fernando Figueira · BRUniversidade de Pernambuco · BRFundação Getulio Vargas · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papillomavirus (HPV) is the major pathogen for cervical lesions. The evasion mechanism of the immune response and persistence of HPV infection can be influenced by polymorphisms (SNPs) in genes associated with transporter associated with antigen processing (TAP), which may change the peptide binding affinity or the TAP expression impacting the efficiency of peptide transport in the secretory pathway, and the presentation of peptides to cytotoxic T lymphocytes. This study aimed to evaluate the role of the

Indexed as

NeoplasmsPapillomavirus InfectionsAntigen PresentationATP-Binding Cassette TransportersFemaleHuman Papillomavirus VirusesHumansMembrane Transport ProteinsPeptidesPolymorphism, Single NucleotideATP-Binding Cassette TransportersMembrane Transport ProteinsPeptidescervical lesionHPVpolymorphismTAP1TAP2

Identifiers

PMID36619767
PMCPMC9811671
OpenAlexW4313468546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.