ArticleFrontiers in cellular and infection microbiology2022
Effect of vaginal flora on clinical outcome of frozen embryo transfer.
Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Reproductive tract and follicular fluid microbiota and probiotic interventions in IVF/ICSI outcomes: a systematic review.BMC pregnancy and childbirth · 2026Pooled it
- Retrospective comparative analysis of pre-IVF vaginal and semen microbiological cultures in infertile couples highlights absence of microbial concordance.Frontiers in cellular and infection microbiology · 2026Article
- Vaginal microbiota in assisted reproduction: determinants, dynamics, and impact on clinical outcomes.Frontiers in microbiology · 2026Review
- Vaginal microbiome and recurrent pregnancy loss.Infection and immunity · 2025Review
- Behind-the-Scenes Actors in Fertility: A Comprehensive Review of the Female Reproductive Tract Microbiome and Its Clinical Relevance.Life (Basel, Switzerland) · 2025Review
- Assessing vaginal microbiome through Vaginal Microecology Evaluation System as a predictor forFrontiers in endocrinology · 2024Article
- Longitudinal analysis of vaginal microbiota during IVF fresh embryo transfer and in early pregnancy.Microbiology spectrum · 2023Article
- Advances in Research on the Relationship between Vaginal Microbiota and Adverse Pregnancy Outcomes and Gynecological Diseases.Microorganisms · 2023Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Vaginal microbiota imbalance is a high risk factor for premature birth, and is closely related to female pelvic inflammation and sexually transmitted diseases. The effect of vaginal microbiota on the outcome of assisted reproductive technology is still unclear. In this study, the vaginal microbial composition and the pregnancy outcome of frozen embryo transfer (FET) was investigated. Methods: From October 2020 to December 2021, 275 FET cycles were selected from the center of reproductive medicine in Affiliated Hospital of Nantong University. Vaginal secretions were collected on the day of endometrium transformation, and smears were Gram stained. According to the Nugent score they were divided into three groups, including normal group, mild dysbiosis group and sever dysbiosis group. The clinical outcomes of each group were compared. Results: In 275 FET cycles, the embryo implantation rate, clinical pregnancy rate and ongoing pregnancy rate in the normal group (66.9%,84.3% and 83.1%) were significantly higher than those in the mild dysbiosis group (45.5%, 57.3% and 49.3%) and in sever dysbiosis group (29.6%, 34.2% and 27%). The difference was statistically significant ( Conclusion: Nugent score is directly related to the clinical outcome of FET. The Lactobacilli-dominant vaginal flora was a favorable factor for the good clinical outcome of FET, while asymptomatic bacterial vaginosis had a negative correlation with the outcome of FET.
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