Evidence map›Paper›PMID 36619744›Full record

ArticleFrontiers in cellular and infection microbiology2022

Gut microbial indicators of metabolic health underlie age-related differences in obesity and diabetes risk among Native Hawaiians and Pacific Islanders.

Riley K Wells, Braden P Kunihiro, Krit Phankitnirundorn, Rafael Peres, Trevor A McCracken, Lesley Umeda, Rosa H Lee, Dong Yoon Kim, Ruben Juarez, Alika K Maunakea

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Riley K WellsDepartment of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI, United States.
Braden P KunihiroDepartment of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, Honolulu, HI, United States.
Krit PhankitnirundornDepartment of Economics, University of Hawaii at Manoa, Honolulu, HI, United States.
Rafael PeresDepartment of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI, United States.
Trevor A McCrackenDepartment of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, Honolulu, HI, United States.
Lesley UmedaDepartment of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI, United States.
Rosa H LeeDepartment of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, Honolulu, HI, United States.
Dong Yoon KimDepartment of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, Honolulu, HI, United States.
Ruben JuarezDepartment of Economics, University of Hawaii at Manoa, Honolulu, HI, United States.
Alika K MaunakeaDepartment of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI, United States.
University of Hawaiʻi at Mānoa · US

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI HELEN C TURNER · 2012 to 2026
$60.3M
The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI Benjamin C. Fogelgren · 2017 to 2026
$59.5M
Translational Pilot Project ProgramP30GM131944 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI WARD, WILLIAM S · 2019 to 2023
$5.9M
Socioecological Determinants of Immunoepigenetic Signatures of Diabetes Risk in Indigenous CommunitiesR01MD016593 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI MAUNAKEA, ALIKA KEOLAOKALANI · 2021 to 2025
$3.3M
Immunoepigenetic-gut microbiome axis in the social networks of health disparate youthR56MD014630 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI MAUNAKEA, ALIKA KEOLAOKALANI · 2019 to 2019
$386k
NIGMS NIH HHS P20 GM103466NIGMS NIH HHS P30 GM131944NIMHD NIH HHS R01 MD016593NIMHD NIH HHS R56 MD014630NIMHD NIH HHS U54 MD007601
6 · The paper itself

Abstract

Native Hawaiians and Pacific Islanders (NHPIs) suffer from higher prevalence of and mortality to type 2 diabetes mellitus (T2DM) than any other major race/ethnic group in Hawaii. Health inequities in this indigenous population was further exacerbated by the SARS-CoV-2 pandemic. T2DM progression and medical complications exacerbated by COVID-19 are partially regulated by the gut microbiome. However, there is limited understanding of the role of gut bacteria in the context of inflammation-related diseases of health disparities including T2DM and obesity. To address these gaps, we used a community-based research approach from a cohort enriched with NHPI residents on the island of Oahu, Hawaii (N=138). Gut microbiome profiling was achieved

Indexed as

Diabetes Mellitus, Type 2Gastrointestinal MicrobiomeObesityGlycated HemoglobinHawaiiHumansNative Hawaiian or Pacific IslanderGlycated Hemoglobinagebody mass indexdiabetesmicrobiomeNative Hawaiianobesity

Identifiers

PMID36619744
PMCPMC9812644
OpenAlexW4313468542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.