Evidence map›Paper›PMID 36619628›Full record

ArticleFrontiers in medicine2022

Extracellular matrix and dermal nerve growth factor dysregulation in prurigo nodularis compared to atopic dermatitis.

Junwen Deng, Varsha Parthasarathy, Melika Marani, Zachary Bordeaux, Kevin Lee, Chi Trinh, Hannah L Cornman, Anusha Kambala, Thomas Pritchard, Shihua Chen and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 41 citations in OpenAlex.

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  8. Itching, Ionic Channels, Immune System, Magnesium and Antioxidants.Clinical, cosmetic and investigational dermatology · 2026
    Review
  9. Matrix Metalloproteinases in Inflammatory Dermatoses.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Junwen DengDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Varsha ParthasarathyDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Melika MaraniDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Zachary BordeauxDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Kevin LeeDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Chi TrinhDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Hannah L CornmanDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Anusha KambalaDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Thomas PritchardDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Shihua ChenDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Nishadh SutariaDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Olusola O OladipoDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Madan M KwatraDepartment of Anesthesiology, Duke University School of Medicine, Durham, NC, United States.
Martin P AlphonseDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Shawn G KwatraDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Johns Hopkins University · USJohns Hopkins Medicine · USDuke University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prurigo nodularis (PN) is a chronic, pruritic, inflammatory skin disease characterized by hyperkeratotic nodules on the trunk and extremities. While there is growing research on the immunological basis of PN, the neuropathic and structural components of PN lesions are unknown. This study examines the inflammatory, neuropathic, and structural pathways in PN compared to atopic dermatitis (AD) using RNA-sequencing of the lesional and non-lesional skin tissue of PN and AD patients, as well as immunohistochemistry analysis of nerve growth factor (NGF), a neurotrophic factor that regulates nerve development. Transcriptomic analysis of skin biopsies revealed that compared to lesional AD skin, lesional PN skin had significantly increased expression of NGF, matrix metalloproteinases, OSM, MCEMP1, IL1α, IL1β, CXCL2, CXCL5, CXCL8, and insulin-like growth factors in PN compared to AD, and decreased expression of CCL13, CCL26, EPHB1, and collagens (COL4/6). Gene set enrichment analysis demonstrated higher enrichment of keratinization, cornified envelope, myelin sheath, TGF-beta signaling, extracellular matrix disassembly, metalloendopeptidase activity, and neurotrophin-TRK receptor signaling pathways in PN. On immunohistochemistry, PN lesions demonstrated higher dermal NGF expression compared to AD. We present novel findings demonstrating increased neurotrophic and extracellular matrix remodeling signatures in PN compared to AD, possibly explaining the morphological differences in their lesions. These signatures may therefore be important components of the PN pathogenesis and may serve as therapeutic targets.

Indexed as

atopic dermatitisimmunenerve growth factorneuropathicprurigo nodularispruritustranscriptome

Identifiers

PMID36619628
PMCPMC9810753
OpenAlexW4313461198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.