ArticleFrontiers in endocrinology2022
Predictive value of novel inflammatory markers platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio in arterial stiffness in patients with diabetes: A propensity score-matched analysis.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 19 citations in OpenAlex.
- The Inflammation Effect in the Association Between Bilirubin and Chronic Kidney Disease in Patients with Type 2 Diabetes: A Retrospective Cohort Study.Journal of inflammation research · 2026Article
- Commentary on "The Association of Circulating Bone Morphogenetic Protein 9 and Arterial Stiffness in Hypertensive Patients".Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Investigating the dietary inflammatory index and pro-inflammatory immune dynamics: insights from a cross-sectional study of severe vs. non-severe coronary artery disease patients.European journal of medical research · 2025Article
- The ratio of extracellular water to total body water serves as a potential predictor of diabetic peripheral neuropathy in patients.Frontiers in endocrinology · 2025Article
- Lung Cancer Biomarkers Associated with Increased Peripheral Arterial Stiffness in Middle-aged Chinese Adults.Journal of atherosclerosis and thrombosis · 2025Article
- Inflammatory Markers as Predictors of Diabetes Mellitus in Patients with Pulmonary Tuberculosis: A Retrospective Analysis of Hematological Parameters and Clinical Features.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Frailty phenotype as mediator between systemic inflammation and osteoporosis and fracture risks: A prospective study.Journal of cachexia, sarcopenia and muscle · 2024Article
- Association of lymphocyte count and serum albumin concentration with telomere length in Chinese sanitation workers.PloS one · 2024Article
- Association between neutrophil-to-lymphocyte ratio and left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2024Article
- Association between monocyte to lymphocyte ratio and diabetic foot ulcer in the population of the US with diabetes based on the 1999-2004 National Health and Nutrition Examination Survey data: a retrospective cross-sectional study.Frontiers in endocrinology · 2024Article
- A Retrospective Analysis of the Association of Neutrophil-Lymphocyte Ratio (NLR) with Anemia in the Saudi Population.Medicina (Kaunas, Lithuania) · 2023Article
- Prognostic value of monocyte-to-lymphocyte ratio for 90-day all-cause mortality in type 2 diabetes mellitus patients with chronic kidney disease.Scientific reports · 2023Article
- Could Blood Cell-Based Inflammatory Markers Be Used to Monitor Response to Biologic Therapy in Psoriasis?Sisli Etfal Hastanesi tip bulteni · 2023Article
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9 authors at 2 institutions in 1 country.
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Abstract
Background: Increased arterial stiffness is common in patients with diabetes, and inflammation is one of the main causes of increased arterial stiffness. Platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR) are novel inflammatory markers that are reproducible, widely available, and easy to measure, and are associated with low costs. This study sought to investigate the predictive value of these novel inflammatory markers in patients with diabetes having arterial stiffness. Methods: We retrospectively included inpatients with diabetes mellitus from the Endocrinology Department of the Chengdu Fifth People's Hospital from June 2021 to May 2022 and collected data on their general information, biochemical indicators, and brachial-ankle pulse wave velocity (baPWV). After propensity matching, the risk relationship between PLR, NLR, and MLR and arterial stiffness was assessed in the recruited patients. Results: A total of 882 hospitalized patients with diabetes were included in this study and categorized into the low baPWV (507 cases) or high baPWV group (375 cases) based on the baPWV. After propensity matching, there were 180 patients in all in the high and low baPWV groups. Univariate and multivariate logistic regression analyses revealed that high PLR, NLR, and MLR were independently associated with an increased risk of arterial stiffness in patients with diabetes. In the receiver operating characteristic curve analysis, the NLR area under the curve (AUC) was 0.7194 (sensitivity = 84.4%, specificity = 51.1%) when distinguishing low baPWV and high baPWV in patients with diabetes, which was higher than that for PLR AUC (0.6477) and MLR AUC (0.6479), and the combined diagnosis for AUC. Conclusions: NLR was superior to PLR, and MLR and combined diagnosis have certain predictive values that indicate the increase in arterial stiffness in patients with diabetes. These predictive values can help with the early identification of increased arterial stiffness in patients with diabetes.
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