Evidence map›Paper›PMID 36619367›Full record

ArticleiScience2023

Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.

Marc Emmenegger, Elena De Cecco, David Lamparter, Raphaël P B Jacquat, Julien Riou, Dominik Menges, Tala Ballouz, Daniel Ebner, Matthias M Schneider, Itzel Condado Morales and 54 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

64 authors.

Marc EmmeneggerInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Elena De CeccoInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
David LamparterHealth2030 Genome Center, 9 Chemin des Mines, 1202 Geneva, Switzerland.
Raphaël P B JacquatCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Julien RiouInstitute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland.
Dominik MengesEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland.
Tala BallouzEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland.
Daniel EbnerTarget Discovery Institute, University of Oxford, Oxford OX3 7FZ, England.
Matthias M SchneiderCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Itzel Condado MoralesInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Berre DoğançayInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Jingjing GuoInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Anne WiedmerInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Julie DomangeInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Marigona ImeriInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Rita MoosInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Chryssa ZografouInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Leyla BatkitarInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Lidia MadrigalInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Dezirae SchneiderInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Chiara TrevisanInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Andres Gonzalez-GuerraInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Alessandra CarrellaInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Irina L DubachDivision of Internal Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.
Catherine K XuCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Georg MeislCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Vasilis KosmoliaptsisDepartment of Surgery, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK.
Tomas MalinauskasDivision of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK.
Nicola Burgess-BrownStructural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
Ray OwensDivision of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK.
Stephanie HatchTarget Discovery Institute, University of Oxford, Oxford OX3 7FZ, England.
Juthathip MongkolsapayaNuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Gavin R ScreatonNuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Katharina SchubertDepartment of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland.
John D HuckDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Feimei LiuDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Florence PojerProtein Production and Structure Core Facility, EPFL SV PTECH PTPSP, 1015 Lausanne, Switzerland.
Kelvin LauProtein Production and Structure Core Facility, EPFL SV PTECH PTPSP, 1015 Lausanne, Switzerland.
David HackerProtein Production and Structure Core Facility, EPFL SV PTECH PTPSP, 1015 Lausanne, Switzerland.
Elsbeth Probst-MüllerDepartment of Immunology, University Hospital Zurich, 8091 Zurich, Switzerland.
Carlo CerviaDepartment of Immunology, University Hospital Zurich, 8091 Zurich, Switzerland.
Jakob NilssonDepartment of Immunology, University Hospital Zurich, 8091 Zurich, Switzerland.
Onur BoymanDepartment of Immunology, University Hospital Zurich, 8091 Zurich, Switzerland.
Lanja SalehInstitute of Clinical Chemistry, University Hospital Zurich, 8091 Zurich, Switzerland.
Katharina SpanausInstitute of Clinical Chemistry, University Hospital Zurich, 8091 Zurich, Switzerland.
Arnold von EckardsteinInstitute of Clinical Chemistry, University Hospital Zurich, 8091 Zurich, Switzerland.
Dominik J SchaerDivision of Internal Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.
Nenad BanDepartment of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland.
Ching-Ju TsaiDepartment of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, 5303 Villigen-PSI, Switzerland.
Jacopo MarinoDepartment of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, 5303 Villigen-PSI, Switzerland.
Gebhard F X SchertlerDepartment of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, 5303 Villigen-PSI, Switzerland.
Nadine EbertInstitute of Virology and Immunology, 3012 Bern, Switzerland.
Volker ThielInstitute of Virology and Immunology, 3012 Bern, Switzerland.
Jochen GottschalkRegional Blood Transfusion Service Zurich, Swiss Red Cross, 8952 Schlieren, Switzerland.
Beat M FreyRegional Blood Transfusion Service Zurich, Swiss Red Cross, 8952 Schlieren, Switzerland.
Regina R ReimannInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Simone HornemannInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.
Aaron M RingDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Tuomas P J KnowlesCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Milo A PuhanEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland.
Christian L AlthausInstitute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland.
Ioannis XenariosHealth2030 Genome Center, 9 Chemin des Mines, 1202 Geneva, Switzerland.
David I StuartDivision of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK.
Adriano AguzziInstitute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.

Funding

Yale Cancer Biology Training GrantT32CA193200 · NCI · YALE UNIVERSITY · PI PETER M GLAZER, Qin Yan · 2016 to 2026
$3.6M
Medical Research Council MR/V001329/1NCI NIH HHS T32 CA193200Wellcome Trust
6 · The paper itself

Abstract

Effective public health measures against SARS-CoV-2 require granular knowledge of population-level immune responses. We developed a Tripartite Automated Blood Immunoassay (TRABI) to assess the IgG response against three SARS-CoV-2 proteins. We used TRABI for continuous seromonitoring of hospital patients and blood donors (n = 72'250) in the canton of Zurich from December 2019 to December 2020 (pre-vaccine period). We found that antibodies waned with a half-life of 75 days, whereas the cumulative incidence rose from 2.3% in June 2020 to 12.2% in mid-December 2020. A follow-up health survey indicated that about 10% of patients infected with wildtype SARS-CoV-2 sustained some symptoms at least twelve months post COVID-19. Crucially, we found no evidence of a difference in long-term complications between those whose infection was symptomatic and those with asymptomatic acute infection. The cohort of asymptomatic SARS-CoV-2-infected subjects represents a resource for the study of chronic and possibly unexpected sequelae.

Indexed as

Biological databaseImmunologyMicrobiologyVirology

Identifiers

PMID36619367
PMCPMC9811913

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.