ArticleAdvanced genetics (Hoboken, N.J.)2020
Aging mechanisms-A perspective mostly from
Article in Advanced genetics (Hoboken, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ageing effects of social environments in 'non-social' insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Pooled it
- Review
- Age-dependent physiological responses and longevity in three Drosophila species with contrasting lifespans exposed to low temperature and constant darkness.Biogerontology · 2026Article
- Enteric viral infections promote systemic accelerated aging inScience advances · 2026Article
- Reserpine prolongs lifespan but compromises locomotion and heat-stress resilience in Drosophila melanogaster.npj aging · 2026Article
- Reply to Maleszka et al.: DNA methylation signals persist across insect metamorphosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dietary sucrose determines the regulatory activity of lithium on gene expression and lifespan inAging · 2024Article
- Genetic, Environmental, and Stochastic Components of Lifespan Variability: TheInternational journal of molecular sciences · 2024Review
- The biology of aging in a social world: Insights from free-ranging rhesus macaques.Neuroscience and biobehavioral reviews · 2023Review
- Use of Farnesyl Transferase Inhibitors in an Ageing Model inJournal of developmental biology · 2023Article
- Generation of LexA enhancer-trap lines in Drosophila by an international scholastic network.G3 (Bethesda, Md.) · 2023Article
- What do we mean by "aging"? Questions and perspectives revealed by studies in Drosophila.Mechanisms of ageing and development · 2023Article
- Rapamycin supplementation ofRoyal Society open science · 2023Article
- The biology of aging in a social world:insights from free-ranging rhesus macaques.bioRxiv : the preprint server for biology · 2023Article
- The Drosophila melanogaster ACE2 ortholog genes are differently expressed in obesity/diabetes and aging models: Implications for COVID-19 pathology.Biochimica et biophysica acta. Molecular basis of disease · 2022Article
- Alterations in biogenic amines levels associated with age-related muscular tissue impairment inSaudi journal of biological sciences · 2022Article
- Inter-Species Rescue of Mutant Phenotype-The Standard for Genetic Analysis of Human Genetic Disorders inInternational journal of molecular sciences · 2022Review
- Sex-specific aging in animals: Perspective and future directions.Aging cell · 2022Review
- The Potential of Calorie Restriction and Calorie Restriction Mimetics in Delaying Aging: Focus on Experimental Models.Nutrients · 2021Review
- Tissue-Specific Knockdown of Genes of the Argonaute Family Modulates Lifespan and Radioresistance in Drosophila Melanogaster.International journal of molecular sciences · 2021Article
Corrections and comments
- Erratum issuedErratum.2021
Authors and funding
2 authors.
Funding
Abstract
A mechanistic understanding of the natural aging process, which is distinct from aging-related disease mechanisms, is essential for developing interventions to extend lifespan or healthspan. Here, we discuss current trends in aging research and address conceptual and experimental challenges in the field. We examine various molecular markers implicated in aging with an emphasis on the role of heterochromatin and epigenetic changes. Studies in model organisms have been advantageous in elucidating conserved genetic and epigenetic mechanisms and assessing interventions that affect aging. We highlight the use of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.