Biotransformation of hydroxychloroquine to evaluate the cytotoxicity of its metabolites and mimic mammalian metabolism.

Valmore Henrique Pereira Dos Santos, Wanderleya Toledo Dos Santos, Marisa Ionta, Ana Cláudia Chagas de Paula, Eliane de Oliveira Silva

Open access · goldAbstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in Results in chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.5field-weighted citation impact, top 37% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Biodegradation of Chloroquine by a Fungus from Amazonian Soil,Journal of fungi (Basel, Switzerland) · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Valmore Henrique Pereira Dos SantosOrganic Chemistry Department, Chemistry Institute, Federal University of Bahia, Salvador, BA, Brazil.

Wanderleya Toledo Dos SantosFaculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil.

Marisa IontaInstitute of Biomedical Sciences, Federal University of Alfenas, Alfenas, MG, Brazil.

Ana Cláudia Chagas de PaulaFaculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil.

Eliane de Oliveira SilvaOrganic Chemistry Department, Chemistry Institute, Federal University of Bahia, Salvador, BA, Brazil.

Universidade Federal da Bahia · BRUniversidade Federal de Juiz de Fora · BRUniversidade Federal de Alfenas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydroxychloroquine (HCQ) displays attractive anti-inflammatory and antiviral effects. Because of that, such a drug made part of some clinical trials for combating Sars-CoV-2 during the COVID-19 pandemic. The present study aimed to conduct the biotransformation of HCQ by filamentous fungi reported as microbial models of mammalian drug metabolism to evaluate its cytotoxic after metabolization.

Indexed as

CytotoxicityFungal biotransformationHydroxychloroquine

Identifiers

PMID36619209

DOI10.1016/j.rechem.2022.100761

PMCPMC9806929

OpenAlexW4313478837

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.