ReviewNew microbes and new infections2023
The global case fatality rate due to COVID-19 in hospitalized elderly patients by sex, year, gross domestic product, and continent: A systematic review, meta-analysis, and meta-regression.
Review in New microbes and new infections, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07527247 (Using AS01 Adjuvant to Improve Immune Response in Older Adults Through Trained Immunity), which is not on this map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Using AS01 Adjuvant to Improve Immune Response in Older Adults Through Trained Immunity
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pregnancy and neonatal outcomes of HIV infection in pregnant women in Iran: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Prevalence of and risk factors for suicidal ideation among perinatal women with HIV infection: a systematic review, meta-analysis, and meta-regression.BMC psychiatry · 2025Pooled it
- Risk of suicide, suicide attempt, and suicidal ideation among people with vitamin D deficiency: a systematic review and meta-analysis.BMC psychiatry · 2025Pooled it
- Availability of malaria diagnostic tests, anti-malarial drugs, and the correctness of treatment: a systematic review and meta-analysis.Malaria journal · 2023Pooled it
- Real-world effectiveness of early remdesivir in reducing mortality among vulnerable patients hospitalized for COVID-19: Evidence for clinical pharmacists and inpatient care providers.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2026Article
- Excess mortality and underlying causes of death during the COVID-19 pandemic in rural Bangladesh: insights from the Matlab health and demographic surveillance system.Population health metrics · 2026Article
- Altitude and case fatality rate from COVID-19 during the pandemic in Peru, 2020-2022.Revista peruana de medicina experimental y salud publica · 2026Article
- Looking beyond the origin of SARS-CoV-2: Significant strategic aspects during the five-year journey of COVID-19 vaccine development.Molecular therapy. Nucleic acids · 2025Review
- Evaluation of Neurosurgery Consultations in Hospitalized Geriatric Patients During and After the COVID-19 Pandemic.Medicina (Kaunas, Lithuania) · 2025Article
- Observational
- Risk factors for diarrheal diseases among pilgrims during Arba'een mass gathering: a case-control study.BMC infectious diseases · 2024Article
- Prior Engagement in Physical Activity Correlates with Enhanced Quality of Life Perceptions among Older Adults during COVID-19 Lockdown.Brain sciences · 2024Article
- Loneliness and its correlation with self-care and activities of daily living among older adults: a partial least squares model.BMC geriatrics · 2024Observational
- Trust in primary health care and COVID-19 vaccine uptake among Iranian pediatric: a web-based cross-sectional survey.BMC pediatrics · 2024Article
- The impact of the COVID-19 pandemic on neurosurgery in the elderly population in Sweden.BMC public health · 2024Observational
- Psychological well-being and factors affecting it after the COVID-19 pandemic.Frontiers in psychology · 2024Article
- COVID-19 outbreaks in residential aged care facilities: an agent-based modeling study.Frontiers in public health · 2024Article
- Unleashing the link between the relaxation of the COVID-19 control policy and residents' mental health in China: the mediating role of family tourism consumption.Frontiers in public health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although elderly people are at a huge risk of mortality due to COVID-19, the Case Fatality Rate (CFR) in hospitalized elderly patients is poorly investigated. This meta-analysis and meta-regression aimed to generate pooled CFR due to COVID-19 in hospitalized elderly patients by sex, Gross Domestic Product (GDP), year, and continent and also to explain the potential source of the heterogeneity and variations in the pooled estimation of COVID-19 CFR. Methods: We systematically searched PubMed, Scopus, Web of Science, CINAHL, and Embase up to 31 July 2022. Eligibility assessment of records was performed independently in a blinded, standardized way by two reviewers. Meta-analysis and Meta-regression analysis were carried out to estimate pooled CFR and the potential sources of the heterogeneity. Results: The study included 5683 confirmed hospitalized elderly COVID-19 patients, 1809 deaths, and 19 original articles from 10 countries. The pooled estimate of the overall CFR, and by male and female sexes were 29%, 34%, and 24%, respectively. We found CFR was decreased by increasing female sex proportion, GDP, and year of publication. Multivariate meta-regression analysis indicated that the age and sex of patients, continent, GDP, and year of the publication together explained the majority of the heterogeneity and variations in the pooled estimate of the hospitalized elderly COVID-19 CFR. Conclusions: This review provided reliable pooled CFR measures for hospitalized elderly patients with COVID-19. Although COVID-19 fatality has decreased in hospitalized elderly patients over time, it is still high in hospitalized elderly patients and needs advanced treatment support.
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