Evidence map›Paper›PMID 36618936›Full record

ReviewFrontiers in pharmacology2022

Role of bioactive compounds in the treatment of hepatitis: A review.

Arpita Roy, Madhura Roy, Amel Gacem, Shreeja Datta, Md Zeyaullah, Khursheed Muzammil, Thoraya A Farghaly, Magda H Abdellattif, Krishna Kumar Yadav, Jesus Simal-Gandara

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review.Cardiovascular & hematological disorders drug targets · 2026
    Pooled it
  2. Pooled it
  3. Review
  4. Antitumor Alkaloids in Tibetan Corydalis: Chemical Diversity and Pharmacological Insights.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  5. An overview of anti-Hepatitis B virus flavonoids and their mechanisms of action.Frontiers in cellular and infection microbiology · 2024
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 4 countries.

Arpita RoyDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, India.
Madhura RoyCentre for Translational and Clinical Research, School of Chemical and Life Sciences, Jamia Hamdard University, New Delhi, India.
Amel GacemDepartment of Physics, Faculty of Sciences, University 20 Août 1955, Skikda, Algeria.
Shreeja DattaBiotechnology Department, Delhi Technological University, Rohini, India.
Md ZeyaullahDepartment of Basic Medical Science, College of Applied Medical Sciences, Khamis Mushait Campus, King Khalid University, Abha, Saudi Arabia.
Khursheed MuzammilDepartment of Public Health, College of Applied Medical Sciences, Khamis Mushait Campus, King Khalid University, Abha, Saudi Arabia.
Thoraya A FarghalyDepartment of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia.
Magda H AbdellattifDepartment of Chemistry, College of Science, Taif University, Taif, Saudi Arabia.
Krishna Kumar YadavFaculty of Science and Technology, Madhyanchal Professional University, Bhopal, India.
Jesus Simal-GandaraNutrition and Bromatology Group, Analytical and Food Chemistry Department, Faculty of Science, Universidade de Vigo, Ourense, Spain.
King Khalid University · SADelhi Technological University · INJamia Hamdard · INSharda University · INTaif University · SAUmm al-Qura University · SAUniversidade de Vigo · ESUniversity of Skikda · DZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis causes liver infection leading to inflammation that is swelling of the liver. They are of various types and detrimental to human beings. Natural products have recently been used to develop antiviral drugs against severe viral infections like viral hepatitis. They are usually extracted from herbs or plants and animals. The naturally derived compounds have demonstrated significant antiviral effects against the hepatitis virus and they interfere with different stages of the life cycle of the virus, viral release, replication, and its host-specific interactions. Antiviral activities have been demonstrated by natural products such as phenylpropanoids, flavonoids, xanthones, anthraquinones, terpenoids, alkaloids, aromatics, etc., against hepatitis B and hepatitis C viruses. The recent studies conducted to understand the viral hepatitis life cycle, more effective naturally derived drugs are being produced with a promising future for the treatment of the infection. This review emphasizes the current strategies for treating hepatitis, their shortcomings, the properties of natural products and their numerous types, clinical trials, and future prospects as potential drugs.

Indexed as

bioactive compoundsclinical trialshepatitisinfectiontreatment strategies

Identifiers

PMID36618936
PMCPMC9810990
OpenAlexW4313465537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.