Evidence map›Paper›PMID 36618821›Full record

ReviewFrontiers in molecular neuroscience2022

The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior.

Dasiel O Borroto-Escuela, Cristina Cuesta-Marti, Alexander Lopez-Salas, Barbara Chruścicka-Smaga, Minerva Crespo-Ramírez, Emiliano Tesoro-Cruz, Daniel A Palacios-Lagunas, Miguel Perez de la Mora, Harriët Schellekens, Kjell Fuxe

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  4. Interaction Between Oxytocin and Dopamine Signaling: Focus on the Striatum.International journal of molecular sciences · 2025
    Review
  5. Article
  6. The psychedelic-peptide paradox: a hormetic hypothesis.Comprehensive psychoneuroendocrinology · 2025
    Review
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  11. Acute, chronic and conditioned effects of intranasal oxytocin in the mu-opioid receptor knockout mouse model of autism: Social context matters.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Dasiel O Borroto-EscuelaDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Cristina Cuesta-MartiAPC Microbiome Ireland, University College Cork Cork, Ireland.
Alexander Lopez-SalasReceptomics and Brain Disorders Lab, Department of Human Physiology, Faculty of Medicine, University of Malaga, Málaga, Spain.
Barbara Chruścicka-SmagaAPC Microbiome Ireland, University College Cork Cork, Ireland.
Minerva Crespo-RamírezInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Emiliano Tesoro-CruzUnidad de Investigación Biomédica en Inmunología e Infectología, Hospital de Infectología, Centro Médico Nacional La Raza, IMSS, Ciudad de México, Mexico.
Daniel A Palacios-LagunasInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Miguel Perez de la MoraInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Harriët SchellekensAPC Microbiome Ireland, University College Cork Cork, Ireland.
Kjell FuxeDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Universidad Nacional Autónoma de México · MXAPC Microbiome Institute · IEKarolinska Institutet · SECentro Médico Nacional La Raza · MXUniversidad de Málaga · ESUniversity College Cork · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last 10 years, it has become increasingly clear that large numbers of axon collaterals extend from the oxytocin (OXT) hypothalamic axons, especially the parvocellular components, to other brain regions. Consequently, the OXT signaling system forms, like other monoamine axons, a rich functional network across several brain regions. In this manuscript, we review the recently indicated higher order G-protein coupled heteroreceptor complexes of the oxytocin receptor (OXTR), and how these,

Indexed as

dopamineghrelinG protein-coupled receptorsheteroreceptor complexesoligomerizationoxytocinserotonin

Identifiers

PMID36618821
PMCPMC9812438
OpenAlexW4313210657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.