Evidence map›Paper›PMID 36618804›Full record

ArticleAnnals of translational medicine2022

Association of

Soroush Merchant, Cynthia A Prows, Fang Yang, Lili Ding, Jacob MacDonald, Xue Zhang, Senthilkumar Sadhasivam, Victor Garcia, Peter Sturm, Vidya Chidambaran

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Associations ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Implementation of CYP2D6-guided opioid therapy at Cincinnati Children's Hospital Medical Center.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Soroush MerchantDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Cynthia A ProwsDivision of Human Genetics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Fang YangDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Lili DingDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jacob MacDonaldUniversity of Cincinnati, Cincinnati, OH, USA.
Xue ZhangDivision of Human Genetics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Senthilkumar SadhasivamDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Victor GarciaDivision of Pediatric General and Thoracic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Peter SturmDivision of Orthopedic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Vidya ChidambaranDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati · USUniversity of Cincinnati Medical Center · US

Funding

JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
Better Outcomes for Children: Promoting Excellence in Healthcare Genomics to Inform PolicyU01HG008666 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI HARLEY, JOHN BARKER · 2015 to 2019
$4.2M
Better Outcomes for Children: GWAS & PheWAS in eMERGEII.U01HG006828 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI HARLEY, JOHN BARKER, HOLM, INGRID ADELE · 2012 to 2014
$4.0M
Effects of Opioid Use Disorder in Pregnancy on Long-Term Maternal and Child OutcomesR01HD096800 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SADHASIVAM, SENTHILKUMAR · 2018 to 2022
$3.1M
Epigenetic Determinants Influencing Development and Evolution of Chronic Post-surgical Pain in Children Undergoing Musculoskeletal Surgery.R01AR075857 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI CHIDAMBARAN, VIDYA · 2019 to 2023
$3.0M
Pharmacogenetics of Oxycodone, Personalized Care and Persistent Surgical PainR01HD089458 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI SADHASIVAM, SENTHILKUMAR · 2016 to 2020
$2.5M
Bedside prediction of opioid-induced respiratory depression in children with pupillometryR21HD094311 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI SADHASIVAM, SENTHILKUMAR · 2018 to 2019
$433k
NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG006828NHGRI NIH HHS U01 HG008666NIAMS NIH HHS R01 AR075857NICHD NIH HHS R01 HD089458NICHD NIH HHS R01 HD096800NICHD NIH HHS R21 HD094311
6 · The paper itself

Abstract

Background: Oxycodone is a commonly used oral opioid in children for treating postoperative pain. Highly polymorphic gene Methods: Patients who underwent Nuss procedure and spine fusion with Results: Of 193 subjects (age 15.9±0.25 years, 28.5% female, 93.78% White; 101 NM, 76 IM, 10 PM and 6 UM), 77.72% underwent pectus surgery. Conclusions: Our findings suggest

Indexed as

analgesiaCYP2D6opioid adverse effectsoxycodonepharmacogeneticspostoperative pain

Identifiers

PMID36618804
PMCPMC9816853
OpenAlexW4312032665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.