Evidence map›Paper›PMID 36618771›Full record

ArticleJournal of bio-X research2022

Antitumor and off-target effects of cholesterol-conjugated let-7a mimics in an orthotopic hepatocellular carcinoma xenograft nude mouse model.

Jian Guan, Mingyang Liu, Xin Li, Liangrui Zhou, Xueyu Dong, Wei Dai, Yu Xia, Tao Yang, Shaojuan Guo, Xingqi Li and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of bio-X research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Jian GuanThe National Population and Health Scientific Data Centre (Clinical Medicine).
Mingyang LiuDepartment of Pathology.
Xin LiDepartment of Nuclear Medicine, Peking Union Medical College Hosptial, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing.
Liangrui ZhouDepartment of Pathology.
Xueyu DongNational Laboratory of Medical Biology, Institute of Basic Medical Sciences.
Wei DaiThe Electron Microscope Laboratories Center, Institute of Basic Medical Sciences.
Yu XiaDepartment of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Tao YangThe National Population and Health Scientific Data Centre (Clinical Medicine).
Shaojuan GuoThe National Population and Health Scientific Data Centre (Clinical Medicine).
Xingqi LiDepartment of Pathology.
Yehua HanThe Electron Microscope Laboratories Center, Institute of Basic Medical Sciences.
Yufeng LuoDepartment of Pathology.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNPeking Union Medical College Hospital · CNInstitute of Basic Medical Sciences of the Chinese Academy of Medical SciencesAcademia Sinica · TWInstitute for Basic Science · KRUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To explore the antitumor and potential off-target effects of systemically delivered cholesterol-conjugated Methods: The antitumor effects of two intravenous dosing regimens of Results: Continuous treatment with Conclusions:

Indexed as

drug-induced renal injuryhepatic toxicityin vivo off target effectslet-7 mimicsnonviral delivery vector

Identifiers

PMID36618771
PMCPMC9810003
OpenAlexW3197147988

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.