Evidence map›Paper›PMID 36618713›Full record

ArticlePulmonary circulation2023

Acute vasoreactivity testing during right heart catheterization in chronic thromboembolic pulmonary hypertension: Results from the pulmonary vascular disease phenomics study.

Robert P Frantz, Jane A Leopold, Paul M Hassoun, Anna R Hemnes, Evelyn M Horn, Stephen C Mathai, Franz P Rischard, A Brett Larive, W H Wilson Tang, Margaret M Park and 2 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Pulmonary circulation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04071327 (Pulmonary Hypertension Association Registry), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04071327 recruitingnot on this map

Pulmonary Hypertension Association Registry

Typeobservational_patient_registrySponsorPulmonary Hypertension Association, Inc.Ran2015 to 2025Enrolled3,000ConditionsPulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Hypertension
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Robert P FrantzDepartment of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA.ORCID 0000-0003-4128-3978
Jane A LeopoldHarvard Medical School Boston Massachusetts USA.
Paul M HassounDivision of Pulmonary and Critical Care Medicine Johns Hopkins University Baltimore Maryland USA.
Anna R HemnesDivision of Allergy, Pulmonary and Critical Care Medicine Vanderbilt University Medical Center Nashville Tennessee USA.
Evelyn M HornDivision of Pulmonary and Critical Care Medicine Johns Hopkins University Baltimore Maryland USA.
Stephen C MathaiDivision of Pulmonary and Critical Care Medicine Johns Hopkins University Baltimore Maryland USA.
Franz P RischardPerkin Heart Failure Center, Division of Cardiology Weill Cornell Medicine New York New York USA.
A Brett LariveDepartment of Quantitative Health Sciences Cleveland Clinic Cleveland Ohio USA.
W H Wilson TangDepartment of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA.
Margaret M ParkDepartment of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA.
Nicholas S HillDivision of Pulmonary, Critical Care, and Sleep Medicine Tufts Medical Center Boston Massachusetts USA.ORCID 0000-0002-8242-8339
Erika B RosenzweigDepartment of Pediatrics and Medicine Columbia University New York New York USA.
Cleveland Clinic · USJohns Hopkins University · USColumbia University · USCornell University · USHarvard University · USMayo Clinic · USTufts Medical Center · USVanderbilt University Medical Center · US

Funding

Pulmonary Vascular Disease Phenomics Program (PVDOMICS) Data Coordinating CenterU01HL125177 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BECK, GERALD J, ERZURUM, SERPIL C. · 2014 to 2020
$20.0M
Genomic and Circulating Predictors of PAH responseR01HL142720 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Anna R Hemnes · 2019 to 2026
$5.0M
Intergrated Endothelial Phenotyping to Redefine Pulmonary HypertensionU01HL125215 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEOPOLD, JANE A, WAXMAN, AARON B · 2014 to 2018
$1.7M
PVDOMICS Defining the Future Fingerprints of Pulmonary Vascular DiseaseU01HL125218 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BERMAN-ROSENZWEIG, ERIKA S., HORN, EVELYN · 2014 to 2018
$1.6M
Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics: Clinical Centers (CC) (U01).U01HL125205 · NHLBI · MAYO CLINIC ROCHESTER · PI FRANTZ, ROBERT PAUL · 2014 to 2018
$1.5M
A molecular phenotype of combined pulmonary hypertensionU01HL125212 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEMNES, ANNA R, NEWMAN, JOHN HUGHES · 2014 to 2018
$1.5M
Phenomic and genomic study to subphenotype Hispanics with pulmonary hypertensionU01HL125208 · NHLBI · UNIVERSITY OF ARIZONA · PI GARCIA, JOE G. N., RISCHARD, FRANZ P · 2014 to 2018
$1.5M
Hopkins Clinical Center for Pulmonary Vascular Disease Phenomics ProgramU01HL125175 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HASSOUN, PAUL M., MATHAI, STEPHEN C · 2015 to 2019
$1.1M
NHLBI NIH HHS R01 HL142720NHLBI NIH HHS U01 HL125175NHLBI NIH HHS U01 HL125177NHLBI NIH HHS U01 HL125205NHLBI NIH HHS U01 HL125208NHLBI NIH HHS U01 HL125212NHLBI NIH HHS U01 HL125215NHLBI NIH HHS U01 HL125218
6 · The paper itself

Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) is believed to involve both vascular obstruction and vasoconstriction; hence, pulmonary vasodilators such as riociguat may be beneficial. Acute vasoreactivity testing (AVT) is seldom performed routinely in CTEPH patients, so there is limited understanding of the frequency and significance of an acute vasodilator response. Systematic vasodilator testing with oxygen (O

Indexed as

catheterizationnitric oxidepulmonary embolismvasoreactivity

Identifiers

PMID36618713
PMCPMC9817070
OpenAlexW4313443279

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.