Evidence map›Paper›PMID 36618488›Full record

ArticleRegenerative therapy2023

Comparative study of differentiating human pluripotent stem cells into vascular smooth muscle cells in hydrogel-based culture methods.

Qing Liu, Zhen Liu, Hongyu Gu, Yuxia Ge, Xuesheng Wu, Fuxing Zuo, Qian Du, Yuguo Lei, Zhanqi Wang, Haishuang Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Qing LiuDepartment of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100006, China.
Zhen LiuDepartment of Neurosurgery, Beijing Shunyi District Hospital, Beijing, 101300, China.
Hongyu GuDepartment of Thoracic Surgery Ward 3, The First Hospital of Qiqihar, Affiliated Qiqihar Hospital, Southern Medical University, Qiqihar, 161005, China.
Yuxia GeDepartment of Neurology, The Second Hospital of Harbin, Harbin, 150056, China.
Xuesheng WuDepartment of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Fuxing ZuoDepartment of Neurosurgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Qian DuDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Yuguo LeiDepartment of Biomedical Engineering, Huck Life Science Institute, Pennsylvania State University, University Park, PA, 16802, USA.
Zhanqi WangDepartment of Vascular Surgery, Beijing Anzhen Hospital of Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, 100029, China.
Haishuang LinDepartment of Neurology, The Second Hospital of Harbin, Harbin, 150056, China.
Capital Medical University · CNHarbin Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNPeking University · CNPennsylvania State University · USShunyi Hospital of Beijing Traditional Chinese Medicine Hospital · CNSouthern Medical University · CNUniversity of Nebraska–Lincoln · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular smooth muscle cells (VSMCs), which provides structural integrity and regulates the diameter of vasculature, are of great potential for modeling vascular-associated diseases and tissue engineering. Here, we presented a detailed comparison of differentiating human pluripotent stem cells (hPSCs) into VSMCs (hPSCs-VSMCs) in four different culture methods, including 2-dimensional (2D) culture, 3-dimensional (3D) PNIPAAm-PEG hydrogel culture, 3-dimensional (3D) alginate hydrogel culture, and transferring 3-dimensional alginate hydrogel culture to 2-dimensional (2D) culture. Both hydrogel-based culture methods could mimic

Indexed as

Alginate hydrogel fiberHuman pluripotent stem cellsIndustrial productionPNIPAAm-PEG hydrogelVascular smooth muscle cells

Identifiers

PMID36618488
PMCPMC9798140
OpenAlexW4313419068

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.