ArticleAdvanced genetics (Hoboken, N.J.)2021
Sickle cell disease is a global prototype for integrative research and healthcare.
Article in Advanced genetics (Hoboken, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Sickle Cell Disease at a Tertiary Care Center in the Vidarbha Region of India: Protocol for a Clinical and Observational Study.JMIR research protocols · 2026Observational
- Academic Proficiency in Ugandan Children With Sickle Cell Anemia: A Cross-Sectional Study.Pediatric blood & cancer · 2025Article
- Innovations in Drug Discovery for Sickle Cell Disease Targeting Oxidative Stress and NRF2 Activation-A Short Review.International journal of molecular sciences · 2025Review
- Improving access to healthcare services for sickle cell disease patients in Nigeria: perspectives and views of healthcare professionals.Frontiers in health services · 2025Article
- Bile Acid-Targeted Hyaluronic Acid Nanoparticles for Enhanced Oral Absorption of Deferoxamine.The AAPS journal · 2024Article
- Validating evidence for the knowledge, management and involvement of dentists in a dental approach to sickle-cell disease.Brazilian oral research · 2024Article
- A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia.Biomedicines · 2023Review
- Gattaca as a lens on contemporary genetics: marking 25 years into the film's "not-too-distant" future.Genetics · 2022Article
- The missing person in gene-environment interactions.Advanced genetics (Hoboken, N.J.) · 2021Article
- Sickle cell disease is a global prototype for integrative research and healthcare.Advanced genetics (Hoboken, N.J.) · 2021Article
- Challenges Faced by Nurses in Transitioning Pediatric Sickle Cell Disease Patients to Adult Care.SAGE open nursingArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differences in health outcomes and treatment responses within and between global populations have been well documented. There is growing recognition of the need to move beyond simple inventories and descriptions of these differences and our linear explanations for them, and gain a better understanding of the multifaceted systems and networks underlying them in order to develop more precise and effective remedies. Typical targets for such integrative research have been common multifactorial diseases. We propose sickle cell disease, one of the most common monogenic diseases, as an ideal candidate for elucidating the complexity of the influences of endogenous and exogenous factors on disease pathophysiology, phenotypic diversity, and variations in responses to treatments at both the individual and population levels. We provide data-informed representations of diverse contributors to sickle cell disease complications that could guide innovative efforts to advance scientific knowledge, clinical practice, and policy formulation related to the disease; help improve outcomes for people worldwide with sickle cell disease; and inform approaches to studying and addressing other diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.