Evidence map›Paper›PMID 36618370›Full record

ArticleFrontiers in immunology2022

Serum cytokine profiling reveals different immune response patterns during general and severe

Zhikun Zhang, Haiwei Dou, Peng Tu, Dawei Shi, Ran Wei, Ruijie Wan, Chunmei Jia, Lihua Ning, Dongmei Wang, Jing Li and 3 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07399717 (Assessing Role of Probiotics in Children Aged 6-36 Months Treated for Pneumonia at Phu Tho Provincial Obstetrics and Pediatrics Hospitals Within 2026-2027), which is not on this map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07399717 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Assessing Role of Probiotics in Children Aged 6-36 Months Treated for Pneumonia at Phu Tho Provincial Obstetrics and Pediatrics Hospitals Within 2026-2027

TypeinterventionalSponsorAnabio R&DRan2026 to 2027Enrolled330ConditionsPneumonia, Pneumonia in ChildrenArmsPlacebo, Navax, Navax-PregMom
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  10. Host immune dysfunction and Mycoplasma pneumoniae immune evasion: dual drivers of pathogenesis in Mycoplasma pneumoniae pneumonia.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
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  19. Comprehensive study of community acquiredWorld journal of clinical pediatrics · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Zhikun ZhangBeijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Haiwei DouBeijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Peng TuBeijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Dawei ShiBeijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Ran WeiBeijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Ruijie WanBeijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Chunmei JiaDepartment of Pediatric, Baotou Fourth Hospital, Baotou, Inner Mongolia, China.
Lihua NingDepartment of Pediatric, Baotou Fourth Hospital, Baotou, Inner Mongolia, China.
Dongmei WangDepartment of Pediatric, Baotou Fourth Hospital, Baotou, Inner Mongolia, China.
Jing LiDepartment of Pediatric, Beijing Chang Ping District Hospital of Traditional Chinese Medicine and Western Medicine, Beijing, China.
Yan DongDepartment of Pediatric, Beijing Chang Ping District Hospital of Traditional Chinese Medicine and Western Medicine, Beijing, China.
Deli XinBeijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Baoping XuDepartment of Respiratory, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Beijing Friendship Hospital · CNFourth Hospital of Inner Mongolia · CNBeijing Chang'an Integrated Traditional Chinese and Western Medicine Hospital · CNCapital Medical University · CNBeijing Children’s Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Mycoplasma pneumoniaePneumonia, MycoplasmaChildChild, PreschoolCytokinesHumansImmunityMatrix Metalloproteinase 2CytokinesMatrix Metalloproteinase 2cytokinesgeneral MPPimmune responseimmune statusMycoplasma pneumoniaesevere MPP

Identifiers

PMID36618370
PMCPMC9813340
OpenAlexW4312187864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.