Evidence map›Paper›PMID 36617964›Full record

Trial reportPsychological medicine2023

The effect of attention bias modification on depressive symptoms in a comorbid sample: a randomized controlled trial.

Ragnhild Bø, Brage Kraft, Mads Lund Pedersen, Jutta Joormann, Rune Jonassen, Kåre Osnes, Catherine J Harmer, Nils Inge Landrø

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04137367 (A Personalized Approach to Effects of Affective Bias Modification on Symptom Change and Rumination), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04137367 nacompletednot on this map

A Personalized Approach to Effects of Affective Bias Modification on Symptom Change and Rumination

TypeinterventionalSponsorUniversity of OsloRan2019 to 2022Enrolled108ConditionsMajor Depressive DisorderArmsAffective bias modification, Sham Affective bias modification
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Ragnhild BøClinical Neuroscience Research Group, Department of Psychology, University of Oslo, Oslo, Norway.ORCID 0000-0002-3809-3084
Brage KraftClinical Neuroscience Research Group, Department of Psychology, University of Oslo, Oslo, Norway.ORCID 0000-0002-1978-5501
Mads Lund PedersenDepartment of Psychology, University of Oslo, Oslo, Norway.
Jutta JoormannAffect Regulation and Cognition Lab, Yale University, USA.ORCID 0000-0002-5531-8513
Rune JonassenFaculty of Health Sciences, Oslo Metropolitan University, Norway.ORCID 0000-0002-5611-4635
Kåre OsnesDivision of Psychiatry, Diakonhjemmet Hospital, Oslo, Norway.ORCID 0000-0002-9002-0464
Catherine J HarmerClinical Neuroscience Research Group, Department of Psychology, University of Oslo, Oslo, Norway.ORCID 0000-0002-1609-8335
Nils Inge LandrøClinical Neuroscience Research Group, Department of Psychology, University of Oslo, Oslo, Norway.ORCID 0000-0003-0354-5148
University of Oslo · NODiakonhjemmet Hospital · NOOsloMet – Oslo Metropolitan University · NOOslo University Hospital · NOYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Department of HealthNCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

backgroundStudies investigating the long-term effect of attention bias modification (ABM) in clinical samples are lacking. This study investigates the 6-months follow-up effect of ABM on depressive symptoms in participant with major depressive disorder with and without comorbid disorders.

methodsWe conducted a double-blind randomized sham-controlled trial in 101 participants between 19 November 2019, and 17 August 2021. Follow-up ended 3 April 2022. Participants were allocated to ABM or sham condition twice daily for 14 consecutive days. Primary outcomes were the total score on the Beck Depression Inventory-II (BDI-II) at 6 months, mean Brief State Rumination Inventory (BSRI) score post-treatment and reduction in BSRI post-treatment. Secondary outcome was change in attentional bias (AB). The trial was preregistered in ClinicalTrials.gov (#NCT04137367).

resultsA total of 118 patients aged 18-65 years were assessed for eligibility, and 101 were randomized and subjected to intention-to-treat analyses. At 6 months, ABM had no effect on depression and anxiety compared to a sham condition. While rumination decreased during the intervention, there was no effect of condition on rumination and AB. Predictor analysis did not reveal differences between participants with ongoing major depressive episode or comorbid anxiety.

conclusionCompared to sham training, there was no effect of ABM on depressive symptoms at 6-months follow-up. Since the intervention failed at modifying AB, it is unclear whether changes in AB are related to long-term outcomes.

Indexed as

Attentional BiasCognitive Behavioral TherapyMajor Depressive DisorderDepressionHumansTreatment OutcomeAttention bias modificationdepressionfollow-uptransdiagnostic

Identifiers

PMID36617964
PMCPMC10520597
OpenAlexW4313824557

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.