Evidence map›Paper›PMID 36617042›Full record

ArticleSensors (Basel, Switzerland)2022

A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants.

Sofie Nilsson, Anton Tokariev, Marjo Metsäranta, Elisabeth Norman, Sampsa Vanhatalo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Sofie NilssonPediatrics, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, 22185 Lund, Sweden.ORCID 0000-0003-0396-8597
Anton TokarievBABA Center, Departments of Pediatrics and Clinical Neurophysiology, Children's Hospital, Helsinki University Hospital Helsinki, 00029 Helsinki, Finland.ORCID 0000-0002-1202-9981
Marjo MetsärantaDepartment of Pediatrics, Helsinki University Hospital, University of Helsinki, 00029 Helsinki, Finland.
Elisabeth NormanPediatrics, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, 22185 Lund, Sweden.ORCID 0000-0001-6346-8899
Sampsa VanhataloBABA Center, Departments of Pediatrics and Clinical Neurophysiology, Children's Hospital, Helsinki University Hospital Helsinki, 00029 Helsinki, Finland.ORCID 0000-0002-9771-7061
Lund University · SEUniversity of Helsinki · FIHelsinki University Hospital · FI

Funding

The Finnish Pediatric Foundation, the Finnish Academy (No.335778, No.332017), Juselius Foundation, Helsinki University Central Hospital, Finland (Professor Sampsa Vanhatalo). (No.335778, No.332017)The Swedish Research Council and Region Skåne regional medical research grants (Elisabeth Norman). The Swedish Research Council and Region Skåne regional medical research grants (Elisabeth Norman).
6 · The paper itself

Abstract

backgroundData on the cerebral effects of analgesic and sedative drugs are needed for the development of safe and effective treatments during neonatal intensive care. Electroencephalography (EEG) is an objective, but interpreter-dependent method for monitoring cortical activity. Quantitative computerized analyses might reveal EEG changes otherwise not detectable.

methodsEEG registrations were retrospectively collected from 21 infants (mean 38.7 gestational weeks; range 27-42) who received dexmedetomidine during neonatal care. The registrations were transformed into computational features and analyzed visually, and with two computational measures quantifying relative and absolute changes in power (range EEG; rEEG) and cortico-cortical synchrony (activation synchrony index; ASI), respectively.

resultsThe visual assessment did not reveal any drug effects. In rEEG analyses, a negative correlation was found between the baseline and the referential frontal (rho = 0.612,

conclusionCerebral effects of dexmedetomidine as determined by EEG in newborn infants are related to cortical activity prior to DEX administration, indicating that higher brain activity levels (higher rEEG) during baseline links to a more pronounced reduction by DEX. The computational measurements indicate drug effects on both overall cortical activity and cortico-cortical communication. These effects were not evident in visual analysis.

Indexed as

DexmedetomidineElectroencephalographyHumansHypnotics and SedativesInfantInfant, NewbornRetrospective StudiesDexmedetomidineHypnotics and Sedativesbrain monitoringdexmedetomidineEEG analysisnewbornsedative drug

Identifiers

PMID36617042
PMCPMC9823798
OpenAlexW4313471565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.