ArticleSensors (Basel, Switzerland)2022
Development of a Paper-Based Analytical Method for the Colorimetric Determination of Calcium in Saliva Samples.
Article in Sensors (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Extraoral Detection of Biomarkers and Pathogens in Saliva: Comprehensive, Panoramic Review.Biosensors · 2026Review
- Rapid Finger-Pump Microfluidic Paper-Based Assay Platform for Monitoring Calcium Ions in Human Biofluids.Biosensors · 2026Article
- Biocompatible and Flexible Cellulose Film for the Reversible Colourimetric Monitoring of pH and Mg (II).Sensors (Basel, Switzerland) · 2026Article
- Hydrogel as a Platform for Point-of-Care Calcium Determination in Blood.Gels (Basel, Switzerland) · 2025Article
- A dual turn-on-off fluorometric probe based on silver sulfide quantum dots for simultaneous assay of creatinine and calcium in complex matrices.RSC advances · 2025Article
- A Low-Cost Colorimetric Assay for the Analytical Determination of Copper Ions with Consumer Electronic Imaging Devices in Natural Water Samples.Molecules (Basel, Switzerland) · 2023Article
- A Novel Equipment-Free Paper-Based Fluorometric Method for the Analytical Determination of Quinine in Soft Drink Samples.Sensors (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel, rapid, and facile method for the colorimetric determination of calcium using micro-analytical paper-based devices (μ-PADs) was developed. The proposed analytical method utilizes the color differences developing, after the addition of calcium, on the surface of the devices because of the complexation reaction of calcium with Methylthymol Blue (MTB) at room temperature, in alkaline pH. The devices were manufactured with chromatographic paper, using wax barriers, and the analytical protocol was easily implemented without the need of any experimental apparatus except for a simple imaging device. The user must regulate the pH, add the solutions on the paper, and measure the color intensity of the formed Ca(II)-MTB complex with a flatbed scanner. The experimental conditions for optimum color development, the possible interfering substances, and the reliability of the paper devices in different preserving conditions were optimized, with satisfactory results. The method exhibited acceptable detection limits (2.9 mg L
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