Evidence map›Paper›PMID 36616459›Full record

ArticlePolymers2022

CD34 Antibody-Coated Biodegradable Fiber Membrane Effectively Corrects Atrial Septal Defect (ASD) by Promoting Endothelialization.

Bin Chu, Xiaoli Li, Shiqiang Fan, Jinmei He, Xiaohong Ge, Hui Li, Changsheng Chen, Zhen Wang, Song Wang, Boning Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Bin ChuSchool of Materials Science and Engineering, Xiamen University of Technology, Xiamen 361024, China.
Xiaoli LiKey Laboratory of Biomedical Materials and Implant Devices, Research Institute, Tsinghua University, Shenzhen 518057, China.
Shiqiang FanPediatric Cardiology, Shenzhen Children's Hospital, Shenzhen 518057, China.
Jinmei HeKey Laboratory of Biomedical Materials and Implant Devices, Research Institute, Tsinghua University, Shenzhen 518057, China.
Xiaohong GeSchool of Materials Science and Engineering, Xiamen University of Technology, Xiamen 361024, China.
Hui LiSchool of Materials Science and Engineering, Xiamen University of Technology, Xiamen 361024, China.
Changsheng ChenKey Laboratory of Biomedical Materials and Implant Devices, Research Institute, Tsinghua University, Shenzhen 518057, China.
Zhen WangKey Laboratory of Biomedical Materials and Implant Devices, Research Institute, Tsinghua University, Shenzhen 518057, China.
Song WangKey Laboratory of Biomedical Materials and Implant Devices, Research Institute, Tsinghua University, Shenzhen 518057, China.
Boning LiPediatric Cardiology, Shenzhen Children's Hospital, Shenzhen 518057, China.
Tsinghua University · CNXiamen University of Technology · CNShenzhen Children's Hospital · CN

Funding

Shenzhen Science and Technology Projects 2021Szvup098Shenzhen Science and Technology Projects JCYJ20200109150605937Shenzhen Science and Technology Projects JCYJ20210324100601005
6 · The paper itself

Abstract

Biodegradable materials are a next-generation invention for the treatment of congenital heart diseases. However, the corresponding technology used to develop ideal biomaterials still presents challenges. We previously reported the first biodegradable atrial septal defect (ASD) occluder made of poly-lactic acid (PLLA). Unfortunately, the PLLA occluder had a limited endothelialization effect. In this study, the surface of the occluder membrane was coated with sericin/CD34 antibodies to promote the growth of endothelial cells and the regeneration of defective tissue and enhance the repair of the atrial septal defect. The physicochemical properties of the coat on the surface of the fiber membrane were characterized. The sericin coat successfully covered the fiber surface of the membrane, and the thickness of the membrane increased with the sericin concentration. The swelling rate reached 230%. The microscopic observation of fluorescently labeled CD34 antibodies showed that the antibodies successfully attached to the fiber membrane; the fluorescence intensity of PLLA-SH5 was particularly high. The in vitro experiment showed that the PLLA-SH-CD34 fiber membrane was biocompatible and promoted the adhesion and proliferation of endothelial cells. According to our findings, the PLLA-SH-CD34 membrane provides a theoretical and technical basis for the research and development of novel biodegradable occluders.

Indexed as

biodegradableCD34 antibodyendothelializationfiber membrane

Identifiers

PMID36616459
PMCPMC9824060
OpenAlexW4312223592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.