ArticlePolymers2022
Crystallinity Dependence of PLLA Hydrophilic Modification during Alkali Hydrolysis.
Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
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- Synergistic Advances in Additive Manufacturing and Surface Engineering for Polymeric Biomedical Devices.ACS polymers Au · 2025Review
- Multilayer surface coating for enhanced anti-inflammation, anti-restenosis, and re-endothelialization in advanced biodegradable vascular stents.Materials today. Bio · 2025Article
- Ecological Composite Materials Based on Polylactide (PLA) and Organic Fillers: Coffee Grounds and Hen Eggshells Produced by the FDM Method: Mechanical, Thermal Properties, Stress Relaxation and Creep.Materials (Basel, Switzerland) · 2025Article
- Article
- Comparison of Different Aliphatic Polyester-Based Microparticles as Protein Delivery Systems.Polymers · 2025Article
- A novel fully biobased material composite for cosmetic packaging applications.Scientific reports · 2025Article
- New block copolymers to form nanofibers with superior mechanical properties and to conjugate signaling molecules directing tissue regeneration.Materials today (Kidlington, England) · 2025Article
- Antibacterial properties of bimetallic nanopattern induced by excimer laser on PTFE nanotextile.Heliyon · 2025Article
- PLLA Coating of Lyophilized Human Bone Allograft for Long-term Release of Antibiotics.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Poly(L-lactic acid) (PLLA) has been extensively used in tissue engineering, in which its surface hydrophilicity plays an important role. In this work, an efficient and green strategy has been developed to tailor surface hydrophilicity via alkali hydrolysis. On one hand, the ester bond in PLLA has been cleaved and generates carboxyl and hydroxyl groups, both of which are beneficial to the improvement of hydrophilicity. On the other hand, the degradation of PLLA increases the roughness on the film surface. The resultant surface wettability of PLLA exhibits crucial dependence on its crystallinity. In the specimen with high crystallinity, the local enrichment of terminal carboxyl and hydroxyl groups in amorphous regions accelerates the degradation of ester group, producing more hydrophilic groups and slit valleys on film surface. The enhanced contact between PLLA and water in aqueous solution (i.e., the Wenzel state) contributes to the synergistic effect between generated hydrophilic groups and surface roughness, facilitating further degradation. Consequently, the hydrophilicity has been improved significantly in the high crystalline case. On the contrary, the competition effect between them leads to the failure of this strategy in the case of low crystallinity.
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Registered trials
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