ReviewNutrients2023
Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid.
Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
135 citing papers in PubMed, 1 synthesis or guideline pooled it, 230 citations in OpenAlex.
- Do oleic acid-enriched oil formulations improve health outcomes in metabolic disorders? A GRADE-assessed meta-analysis.Frontiers in nutrition · 2026Pooled it
- Assessing the Potential of an Enzymatically Liberated Salmon Oil to Support Immune Health Recovery from Acute SARS-CoV-2 Infection via Change in the Expression of Cytokine, Chemokine and Interferon-Related Genes.International journal of molecular sciences · 2024Trial
- The diet supplemented with raw and hydrolyzed Microchloropsis gaditana and Arthrospira platensis blend modulates intestinal microbiota and metabolomic profiles in Sparus aurata.Fish physiology and biochemistry · 2026Article
- Comparative Therapeutic Effects of Lipid-Enriched and Ethanolic Garlic Extracts on DMBA-Induced Hepatic Carcinogenesis in Mice.Applied biochemistry and biotechnology · 2026Article
- Exploring GC-MS-Based Phytochemistry and Network Pharmacology to Elucidate the Multi-Target Therapeutic Potential of Betel Leaf Oil as an Analgesic and Anti-Inflammatory Agent.Biomedical chromatography : BMC · 2026Article
- Genome editing generates high oleic soybean and eliminates beany flavors.Journal of integrative plant biology · 2026Article
- Advantages of a Multi-Platform Workflow Integrating Biphasic Extraction, Chromatography, and NMR for Characterization of Metabolites in Extracts ofMetabolites · 2026Article
- Determining the metabolic profile measured using ultra-high pressure liquid chromatography associated with Beta Amyloid burden in the brain in individuals with mild cognitive impairment.Research square · 2026Article
- Selective Pharmacological Activation of PPARα/δ/γ Alters the Triglyceride Composition of Fatty Liver in a Diet-Induced MASLD Mouse Model.Biomolecules · 2026Article
- The Associations Between Habitual Dietary Fat Intake and Inflammatory Markers Among Marathon Runners: An Exploratory Study.Nutrients · 2026Article
- Unveiling Microbial Dynamics in the Spontaneous Fermentation of Oat and Rice Okara Sourdoughs.Foods (Basel, Switzerland) · 2026Article
- Review
- Tissue-specific roles of monoacylglycerol (MAG) in metabolic diseases.Immunometabolism (Cobham, Surrey) · 2026Review
- Syagrus coronata fixed oil attenuates inflammation, oxidative stress and pulmonary alterations in L-arginine-induced pancreatitis.Inflammopharmacology · 2026Article
- Influence of Extraction Methods on the Physicochemical and Biological Properties of Amazonian Beetle Larva Oil (ACS omega · 2026Article
- In Vitro Regeneration ofAntioxidants (Basel, Switzerland) · 2026Article
- Article
- Oleic acid fuels cisplatin-resistant ovarian cancer through FABP4-driven lipid uptake.Molecular metabolism · 2026Article
- Bioactive Potential ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Exploring the functional and immunological diversity of the fatty acid-binding protein (FABP) family in Fasciola hepatica.Scientific reports · 2026Article
75 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
In 2010, the Mediterranean diet was recognized by UNESCO as an Intangible Cultural Heritage of Humanity. Olive oil is the most characteristic food of this diet due to its high nutraceutical value. The positive effects of olive oil have often been attributed to its minor components; however, its oleic acid (OA) content (70-80%) is responsible for its many health properties. OA is an effective biomolecule, although the mechanism by which OA mediates beneficial physiological effects is not fully understood. OA influences cell membrane fluidity, receptors, intracellular signaling pathways, and gene expression. OA may directly regulate both the synthesis and activities of antioxidant enzymes. The anti-inflammatory effect may be related to the inhibition of proinflammatory cytokines and the activation of anti-inflammatory ones. The best-characterized mechanism highlights OA as a natural activator of sirtuin 1 (SIRT1). Oleoylethanolamide (OEA), derived from OA, is an endogenous ligand of the peroxisome proliferator-activated receptor alpha (PPARα) nuclear receptor. OEA regulates dietary fat intake and energy homeostasis and has therefore been suggested to be a potential therapeutic agent for the treatment of obesity. OEA has anti-inflammatory and antioxidant effects. The beneficial effects of olive oil may be related to the actions of OEA. New evidence suggests that oleic acid may influence epigenetic mechanisms, opening a new avenue in the exploration of therapies based on these mechanisms. OA can exert beneficial anti-inflammatory effects by regulating microRNA expression. In this review, we examine the cellular reactions and intracellular processes triggered by OA in T cells, macrophages, and neutrophils in order to better understand the immune modulation exerted by OA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.