Evidence map›Paper›PMID 36615819›Full record

ReviewNutrients2022

What Is the Evidence for Dietary-Induced DHA Deficiency in Human Brains?

Andrew J Sinclair, Yonghua Wang, Duo Li

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Navigating my career in lipid research.European journal of clinical nutrition · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Andrew J SinclairDepartment of Nutrition, Dietetics and Food, School of Clinical Sciences, Monash University, Notting Hill, VIC 3168, Australia.ORCID 0000-0002-9515-9721
Yonghua WangSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Duo LiInstitute of Nutrition & Health, College of Public Health, Qingdao University, Qingdao 266071, China.ORCID 0000-0001-5227-5565
Deakin University · AUQingdao University · CNSouth China University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Docosahexaenoic acid (DHA) is a major constituent of neural and visual membranes and is required for optimal neural and visual function. DHA is derived from food or by endogenous synthesis from α-linolenic acid (ALA), an essential fatty acid. Low blood levels of DHA in some westernised populations have led to speculations that child development disorders and various neurological conditions are associated with sub-optimal neural DHA levels, a proposition which has been supported by the supplement industry. This review searched for evidence of deficiency of DHA in human populations, based on elevated levels of the biochemical marker of

Indexed as

Docosahexaenoic AcidsFatty Acids, EssentialAdolescentAdultalpha-Linolenic AcidAnimalsBrainChildFemaleHumansInfantInfant, NewbornMilkParturitionPregnancyalpha-Linolenic AcidDocosahexaenoic AcidsFatty Acids, Essentialalpha-linolenic acid (ALA)braindeficiency of ALAdeficiency of DHAdocosahexaenoic acid (DHA)docosapentaenoic acid (22:5n-6)humanveganvegetarian

Identifiers

PMID36615819
PMCPMC9824463
OpenAlexW4313294827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.