Evidence map›Paper›PMID 36615766›Full record

ReviewNutrients2022

Influence of Oxidative Stress and Inflammation on Nutritional Status and Neural Plasticity: New Perspectives on Post-Stroke Neurorehabilitative Outcome.

Irene Ciancarelli, Giovanni Morone, Marco Iosa, Antonio Cerasa, Rocco Salvatore Calabrò, Giovanni Iolascon, Francesca Gimigliano, Paolo Tonin, Maria Giuliana Tozzi Ciancarelli

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Irene CiancarelliDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Giovanni MoroneDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0003-3602-4197
Marco IosaDepartment of Psychology, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-2434-3887
Antonio CerasaInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy, 98164 Messina, Italy.
Rocco Salvatore CalabròIRCCS Centro Neurolesi "Bonino-Pulejo", 98123 Messina, Italy.ORCID 0000-0002-8566-3166
Giovanni IolasconDepartment of Medical and Surgical Specialties and Dentistry, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy.ORCID 0000-0002-0976-925X
Francesca GimiglianoDepartment of Mental and Physical Health and Preventive Medicine, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy.
Paolo ToninS. Anna Institute, 88900 Crotone, Italy.
Maria Giuliana Tozzi CiancarelliDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
University of L'Aquila · ITIstituto S.Anna Crotone · ITUniversity of Campania "Luigi Vanvitelli" · ITCentro Neurolesi Bonino Pulejo · ITFondazione Santa Lucia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beyond brain deficits caused by strokes, the effectiveness of neurorehabilitation is strongly influenced by the baseline clinical features of stroke patients, including a patient's current nutritional status. Malnutrition, either as a pre-stroke existing condition or occurring because of ischemic injury, predisposes patients to poor rehabilitation outcomes. On the other hand, a proper nutritional status compliant with the specific needs required by the process of brain recovery plays a key role in post-stroke rehabilitative outcome favoring neuroplasticity mechanisms. Oxidative stress and inflammation play a role in stroke-associated malnutrition, as well as in the cascade of ischemic events in the brain area, where ischemic damage leads to neuronal death and brain infarction, and, via cell-to-cell signaling, the alteration of neuroplasticity processes underlying functional recovery induced by multidisciplinary rehabilitative treatment. Nutrition strategies based on food components with oxidative and anti-inflammatory properties may help to reverse or stop malnutrition and may be a prerequisite for supporting the ability of neuronal plasticity to result in satisfactory rehabilitative outcome in stroke patients. To expand nutritional recommendations for functional rehabilitation recovery, studies considering the evolution of nutritional status changes in post-stroke patients over time are required. The assessment of nutritional status must be included as a routine tool in rehabilitation settings for the integrated care of stroke-patients.

Indexed as

MalnutritionStrokeStroke RehabilitationHumansInflammationNeuronal PlasticityNutritional StatusOxidative Stresshealthy dietary patternsmalnutritionneuroplasticitynutritional statusoxidative stressrehabilitationstroke

Identifiers

PMID36615766
PMCPMC9823808
OpenAlexW4313244568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.