ReviewMolecules (Basel, Switzerland)2023
Stereoselective Synthesis of Flavonoids: A Brief Overview.
Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Phytochemistry and Pharmacological Potential of the GenusPharmaceuticals (Basel, Switzerland) · 2026Review
- Cashew-Derived Flavonoids Modulate the Th1/Th2 Balance at Peyer's Patches via a C-Ring Oxidation-Dependent Molecular Switch.Journal of food science · 2026Article
- Effects of Dietary Bamboo Leaf Flavonoids on Egg Quality, Liver Health, and Inflammatory Responses in Aged Laying Hens.Animals : an open access journal from MDPI · 2026Article
- Preparation and Bioactivity Evaluation of Novel Dihydrotanshinone I Derivatives via Biotransformation byJournal of fungi (Basel, Switzerland) · 2026Article
- Flavonoids as colchicine binding site inhibitors: emerging scaffolds in anticancer drug design.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Review
- Synthesis and Evaluation of the Antiproliferative Activity of the Derivatives of 3,5-Diaryl-3,4-dihydro-2Molecules (Basel, Switzerland) · 2025Article
- Recent Advances in the Mitsunobu and Related Reactions: A Review from 2010 to 2024.Topics in current chemistry (Cham) · 2025Review
- Synthesis of fused-ring systems and diarylmethane flavonoidsRSC advances · 2025Article
- Exploring Type II Diabetes Inhibitors from Genus Daphne Plant-species: An Integrated Computational Study.Combinatorial chemistry & high throughput screening · 2025Article
- Ru(II)-Catalyzed Asymmetric Transfer Hydrogenation of α-Alkyl-β-Ketoaldehydes via Dynamic Kinetic Resolution.Molecules (Basel, Switzerland) · 2024Article
- Metabolic Engineering ofMolecules (Basel, Switzerland) · 2024Review
- Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones.ACS medicinal chemistry letters · 2024Article
- Synthetic Studies toward 5,6,7,3',4'-Monomethoxytetrahydroxyflavones: Synthesis of Pedalitin.Molecules (Basel, Switzerland) · 2024Article
- Neuroprotective Potential of Flavonoids in Brain Disorders.Brain sciences · 2023Review
- The Classification, Molecular Structure and Biological Biosynthesis of Flavonoids, and Their Roles in Biotic and Abiotic Stresses.Molecules (Basel, Switzerland) · 2023Review
- Cytotoxic, Antibacterial, and Antioxidant Activities of the Leaf Extract ofPlants (Basel, Switzerland) · 2023Article
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Abstract
Stereoselective synthesis has been emerging as a resourceful tool because it enables the obtaining of compounds with biological interest and high enantiomeric purity. Flavonoids are natural products with several biological activities. Owing to their biological potential and aiming to achieve enantiomerically pure forms, several methodologies of stereoselective synthesis have been implemented. Those approaches encompass stereoselective chalcone epoxidation, Sharpless asymmetric dihydroxylation, Mitsunobu reaction, and the cycloaddition of 1,4-benzoquinone. Chiral auxiliaries, organo-, organometallic, and biocatalysis, as well as the chiral pool approach were also employed with the goal of obtaining chiral bioactive flavonoids with a high enantiomeric ratio. Additionally, the employment of the Diels-Alder reaction based on the stereodivergent reaction on a racemic mixture strategy or using catalyst complexes to synthesise pure enantiomers of flavonoids was reported. Furthermore, biomimetic pathways displayed another approach as illustrated by the asymmetric coupling of 2-hydroxychalcones driven by visible light. Recently, an asymmetric transfer hydrogen-dynamic kinetic resolution was also applied to synthesise (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.