A Novel Multi-Target Mu/Delta Opioid Receptor Agonist, HAGD, Produced Potent Peripheral Antinociception with Limited Side Effects in Mice and Minimal Impact on Human Sperm Motility In Vitro.

Fangfang Li, Feng Yue, Wei Zhang, Biao Xu, Yiqing Wang, Xuehong Zhang

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 58% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fangfang LiThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China.ORCID 0000-0003-3446-1289

Feng YueKey Laboratory for Reproductive Medicine and Embryo of Gansu, Gansu International Scientific and Technological Cooperation Base of Reproductive Medicine Transformation Application, Lanzhou 730000, China.

Wei ZhangKey Laboratory for Reproductive Medicine and Embryo of Gansu, Gansu International Scientific and Technological Cooperation Base of Reproductive Medicine Transformation Application, Lanzhou 730000, China.

Biao XuKey Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.

Yiqing WangThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China.

Xuehong ZhangThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China.

Lanzhou University · CN

Funding

the National Natural Science Foundation of China (81960624)

6 · The paper itself

Abstract

Pain is a common clinical symptom among patients. Although various opioid analgesics have been developed, their side effects hinder their application. This study aimed to develop a novel opioid analgesic, HAGD (H-Tyr-D-AIa-GIy-Phe-NH

Indexed as

Analgesics, OpioidDrug-Related Side Effects and Adverse ReactionsAnimalsCHO CellsCricetinaeCricetulusHumansMaleMiceMorphinePainReceptors, Opioid, deltaReceptors, Opioid, muSemenSperm MotilityAnalgesics, OpioidMorphineReceptors, Opioid, deltaReceptors, Opioid, muanalgesicinfertilityopioidpainsperm motility

Identifiers

PMID36615612

DOI10.3390/molecules28010427

PMCPMC9824695

OpenAlexW4313588144

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.