Evidence map›Paper›PMID 36615578›Full record

ArticleMolecules (Basel, Switzerland)2023

Synthesis, Structural and Behavioral Studies of Indole Derivatives D2AAK5, D2AAK6 and D2AAK7 as Serotonin 5-HT

Agnieszka A Kaczor, Ewa Kędzierska, Tomasz M Wróbel, Angelika Grudzińska, Angelika Pawlak, Tuomo Laitinen, Agata Bartyzel

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Discovery of aporphine derivatives with improved antidepressant activity by regulating SERT and 5-HTMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Agnieszka A KaczorDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki St., PL-20093 Lublin, Poland.ORCID 0000-0001-8679-9623
Ewa KędzierskaDepartment of Pharmacology and Pharmacodynamics, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki St., PL-20093 Lublin, Poland.
Tomasz M WróbelDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki St., PL-20093 Lublin, Poland.ORCID 0000-0002-0313-2522
Angelika GrudzińskaDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki St., PL-20093 Lublin, Poland.ORCID 0000-0001-9658-5418
Angelika PawlakDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki St., PL-20093 Lublin, Poland.
Tuomo LaitinenSchool of Pharmacy, University of Eastern Finland, FI-70211 Kuopio, Finland.
Agata BartyzelDepartment of General and Coordination Chemistry and Crystallography, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Skłodowska University, M. Curie-Skłodowskiej Sq. 2, PL-20031 Lublin, Poland.ORCID 0000-0003-3765-6997
Medical University of Lublin · PLMaria Curie-Skłodowska University · PLUniversity of Eastern Finland · FI

Funding

Medical University of Lublin DS33
6 · The paper itself

Abstract

Serotonin receptors are involved in a number of physiological functions and regulate aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation. Here we report synthesis and detailed structural and behavioral studies of three indole derivatives: D2AAK5, D2AAK6, and D2AAK7 as serotonin 5-HT

Indexed as

Antipsychotic AgentsSerotoninLigandsProtein BindingReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2AReceptors, SerotoninAntipsychotic AgentsLigandsReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2AReceptors, SerotoninSerotoninanxietydepressiondrug designGPCRsindole derivativesmolecular modelingX-ray studies

Identifiers

PMID36615578
PMCPMC9823611
OpenAlexW4313433014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.