Evidence map›Paper›PMID 36615458›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis and Antiproliferative Activity against Cancer Cells of Indole-Aryl-Amide Derivatives.

Junwei Zhao, Jacopo Carbone, Giovanna Farruggia, Anna Janecka, Luca Gentilucci, Natalia Calonghi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Junwei ZhaoDepartment of Chemistry "G. Ciamician", University of Bologna, Via Selmi 2, 40126 Bologna, Italy.
Jacopo CarboneDepartment of Chemistry "G. Ciamician", University of Bologna, Via Selmi 2, 40126 Bologna, Italy.ORCID 0000-0002-8743-7859
Giovanna FarruggiaDepartment of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.ORCID 0000-0003-3599-7034
Anna JaneckaDepartment of Biomolecular Chemistry, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland.
Luca GentilucciDepartment of Chemistry "G. Ciamician", University of Bologna, Via Selmi 2, 40126 Bologna, Italy.ORCID 0000-0001-9134-3161
Natalia CalonghiDepartment of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.
University of Bologna · ITMedical University of Lodz · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Indoles constitute a large family of heterocyclic compounds widely occurring in nature which are present in a number of bioactive natural and synthetic compounds, including anticancer agents or atypical opioid agonists. As a result, exponential increases in the development of novel methods for the synthesis of indole-containing compounds have been reported in the literature. A series of indole-aryl amide derivatives

Indexed as

Antineoplastic AgentsNeoplasmsAmidesAnalgesics, OpioidApoptosisCell Cycle CheckpointsCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansIndolesMolecular StructureStructure-Activity RelationshipAmidesAnalgesics, OpioidAntineoplastic AgentsIndolesanticancercolon cancerindole nucleusmolecular dockingκ-opioid receptor

Identifiers

PMID36615458
PMCPMC9822155
OpenAlexW4313327466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.