Sequential Iron-Catalyzed C(sp

Elwira Bisz, Pamela Podchorodecka, Hengzhao Li, Wioletta Ochędzan-Siodłak, Jie An, Michal Szostak

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Elwira BiszDepartment of Chemistry, Opole University, 48 Oleska Street, 45-052 Opole, Poland.ORCID 0000-0002-7070-2468

Pamela PodchorodeckaDepartment of Chemistry, Opole University, 48 Oleska Street, 45-052 Opole, Poland.

Hengzhao LiDepartment of Nutrition and Health, China Agricultural University, Beijing 100193, China.

Wioletta Ochędzan-SiodłakDepartment of Chemistry, Opole University, 48 Oleska Street, 45-052 Opole, Poland.

Jie AnDepartment of Nutrition and Health, China Agricultural University, Beijing 100193, China.ORCID 0000-0002-1521-009X

Michal SzostakDepartment of Chemistry, Rutgers University, 73 Warren Street, Newark, NJ 07102, USA.ORCID 0000-0002-9650-9690

Funding

National Science Center 2019/35/D/ST4/00806National Science Foundation CAREER CHE-1650766

6 · The paper itself

Abstract

Benzylic alcohols are among the most important intermediates in organic synthesis. Recently, the use of abundant metals has attracted significant attention due to the issues with the scarcity of platinum group metals. Herein, we report a sequential method for the synthesis of benzylic alcohols by a merger of iron catalyzed cross-coupling and highly chemoselective reduction of benzamides promoted by sodium dispersion in the presence of alcoholic donors. The method has been further extended to the synthesis of deuterated benzylic alcohols. The iron-catalyzed Kumada cross-coupling exploits the high stability of benzamide bonds, enabling challenging C(sp

Indexed as

AmidesIronAlcoholsBenzyl AlcoholCatalysisOxidation-ReductionAlcoholsAmidesBenzyl AlcoholIronamidesbenzylic alcoholschemoselective reductioncross-couplingdeuterated compoundsironiron catalysisN–C cleavagesequential catalysissodium

Identifiers

PMID36615417

DOI10.3390/molecules28010223

PMCPMC9821805

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