Evidence map›Paper›PMID 36615383›Full record

ArticleMolecules (Basel, Switzerland)2022

A Study on the Chemistry and Biological Activity of 26-Sulfur Analogs of Diosgenin: Synthesis of 26-Thiodiosgenin

Aneta M Tomkiel, Dorota Czajkowska-Szczykowska, Ewa Olchowik-Grabarek, Lucie Rárová, Szymon Sękowski, Jacek W Morzycki

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aneta M TomkielLaboratory of Natural Products, Department of Organic Chemistry, Faculty of Chemistry, University of Bialystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland.ORCID 0000-0001-7429-1566
Dorota Czajkowska-SzczykowskaLaboratory of Natural Products, Department of Organic Chemistry, Faculty of Chemistry, University of Bialystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland.ORCID 0000-0002-7297-7422
Ewa Olchowik-GrabarekLaboratory of Molecular Biophysics, Department of Microbiology and Biotechnology, Faculty of Biology, University of Bialystok, K. Ciołkowskiego 1 J, 15-245 Białystok, Poland.
Lucie RárováDepartment of Experimental Biology, Faculty of Science, Palacký University, Šlechtitelů 27, CZ-78371 Olomouc, Czech Republic.ORCID 0000-0002-3300-007X
Szymon SękowskiLaboratory of Molecular Biophysics, Department of Microbiology and Biotechnology, Faculty of Biology, University of Bialystok, K. Ciołkowskiego 1 J, 15-245 Białystok, Poland.
Jacek W MorzyckiLaboratory of Natural Products, Department of Organic Chemistry, Faculty of Chemistry, University of Bialystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland.ORCID 0000-0002-9049-5670

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A chemoselective procedure for MCPBA oxidation of 26-thiodiosgenin to corresponding sulfoxides and sulfone was elaborated. An unusual equilibration of sulfoxides in solution was observed. Moreover, α-alkylation of sulfoxide and sulfone was investigated. Finally, the biological activity of obtained compounds was examined.

Indexed as

DiosgeninOxidation-ReductionSulfonesSulfoxidesSulfurDiosgeninSulfonesSulfoxidesSulfur26-thiodiosgeninantimicrobial activitycytotoxicitysapogeninssteroidssulfonessulfoxidesthiol oxidation

Identifiers

PMID36615383
PMCPMC9822051

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.