Evidence map›Paper›PMID 36615282›Full record

ArticleMolecules (Basel, Switzerland)2022

Ring-Modified Histidine-Containing Cationic Short Peptides Exhibit Anticryptococcal Activity by Cellular Disruption.

Komal Sharma, Shams Aaghaz, Indresh Kumar Maurya, Shreya Singh, Shivaprakash M Rudramurthy, Vinod Kumar, Kulbhushan Tikoo, Rahul Jain

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Komal SharmaDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar 160 062, Punjab, India.
Shams AaghazDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar 160 062, Punjab, India.
Indresh Kumar MauryaCenter of Infectious Diseases, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar 160 062, Punjab, India.
Shreya SinghDepartment of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160 012, India.
Shivaprakash M RudramurthyDepartment of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160 012, India.ORCID 0000-0002-9097-9253
Vinod KumarDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar 160 062, Punjab, India.
Kulbhushan TikooDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar 160 062, Punjab, India.
Rahul JainDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar 160 062, Punjab, India.ORCID 0000-0002-9180-2812
National Institute of Pharmaceutical Education and Research · INNational Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad · INPost Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Delineation of clinical complications secondary to fungal infections, such as cryptococcal meningitis, and the concurrent emergence of multidrug resistance in large population subsets necessitates the need for the development of new classes of antifungals. Herein, we report a series of ring-modified histidine-containing short cationic peptides exhibiting anticryptococcal activity via membrane lysis. The

Indexed as

Cryptococcus neoformansHistidineAmphotericin BAntifungal AgentsDipeptidesMicrobial Sensitivity TestsPeptidesAmphotericin BAntifungal AgentsDipeptidesHistidinePeptidesanticryptococcal activityantifungal agentscell lysisiodinated histidinesiodopeptidesmembrane active peptidespore formation

Identifiers

PMID36615282
PMCPMC9821961
OpenAlexW4312174605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.