Evidence map›Paper›PMID 36615199›Full record

ReviewMolecules (Basel, Switzerland)2022

Medicinal Chemistry of Anti-HIV-1 Latency Chemotherapeutics: Biotargets, Binding Modes and Structure-Activity Relationship Investigation.

Yan-Kai Wang, Long Wei, Wei Hu, Pei-Xia Yu, Zhong Li, Hai-Peng Yu, Xun Li

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Yan-Kai WangSchool of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Laboratory for Rare & Uncommon Disease of Shandong Province, No 6699, Qingdao Road, Ji'nan 250117, China; Key Laboratory of Forensic Toxicology, Ministry of Public Security, Beijing 100192, China.
Long WeiSchool of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Laboratory for Rare & Uncommon Disease of Shandong Province, No 6699, Qingdao Road, Ji'nan 250117, China; Key Laboratory of Forensic Toxicology, Ministry of Public Security, Beijing 100192, China.
Wei HuShandong University, No 72, Binhai Road, Qingdao 266237, China.
Pei-Xia YuShandong University, No 72, Binhai Road, Qingdao 266237, China.
Zhong LiShandong University, No 72, Binhai Road, Qingdao 266237, China.
Hai-Peng YuShandong University, No 72, Binhai Road, Qingdao 266237, China.
Xun LiSchool of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Laboratory for Rare & Uncommon Disease of Shandong Province, No 6699, Qingdao Road, Ji'nan 250117, China; Key Laboratory of Forensic Toxicology, Ministry of Public Security, Beijing 100192, China.
Qingdao Binhai University · CNShandong First Medical University · CNShandong University · CNMinistry of Public Security of the People's Republic of China · CN

Funding

Academic promotion program of Shandong First Medical University 2019LJ003Key Laboratory of Forensic Toxicology, Ministry of Public Security 2021FTDWFX04National Key research & Development Program of China 2021YFC2101000Natural Science Foundation of Shandong Province ZR2021MH276
6 · The paper itself

Abstract

The existence of latent viral reservoirs (LVRs), also called latent cells, has long been an acknowledged stubborn hurdle for effective treatment of HIV-1/AIDS. This stable and heterogeneous reservoir, which mainly exists in resting memory CD4

Indexed as

Anti-HIV AgentsHIV-1HIV InfectionsVirus LatencyCD4-Positive T-LymphocytesChemistry, PharmaceuticalHumansStructure-Activity RelationshipVirus ActivationAnti-HIV Agentsanti-HIV-1-latencyHIV-1latency-reversing agents (LRAs)latent reservoirs (LVRs)resting CD4+ T cells (rCD4s)

Identifiers

PMID36615199
PMCPMC9822059
OpenAlexW4313461443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.