Evidence map›Paper›PMID 36615137›Full record

ArticleJournal of clinical medicine2023

Neonatal Hepatic Myeloid Progenitors Expand and Propagate Liver Injury in Mice.

Anas Alkhani, Cathrine Korsholm, Claire S Levy, Sarah Mohamedaly, Caroline C Duwaerts, Eric M Pietras, Amar Nijagal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Immunology of Biliary Atresia.Seminars in pediatric surgery · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Anas AlkhaniDepartment of Surgery, University of California, San Francisco, CA 94143, USA.
Cathrine KorsholmDepartment of Surgery, University of California, San Francisco, CA 94143, USA.
Claire S LevyDepartment of Surgery, University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-9265-6645
Sarah MohamedalyDepartment of Surgery, University of California, San Francisco, CA 94143, USA.
Caroline C DuwaertsThe Liver Center, University of California, San Francisco, CA 94143, USA.
Eric M PietrasDivision of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-7339-8828
Amar NijagalDepartment of Surgery, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-2200-6887
University of California, San Francisco · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Copenhagen · DK

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Y. Chen · 1986 to 2026
$30.7M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
Impact of IL-1 signaling on hematopoietic stem cell function and emergence of clonal hematopoiesis.R01DK119394 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI PIETRAS, ERIC M · 2019 to 2023
$2.0M
American College of Surgeons Faculty Research FellowshipAmerican Pediatric Surgical Association Jay Grosfeld Scholar AwardLundbeck Foundation Danish-American Research Exchange ProgramNIDDK NIH HHS P30 DK026743NIDDK NIH HHS P30 DK063720NIDDK NIH HHS R01 DK119394
6 · The paper itself

Abstract

backgroundBiliary atresia (BA) is a progressive pediatric inflammatory disease of the liver that leads to cirrhosis and necessitates liver transplantation. The rapid progression from liver injury to liver failure in children with BA suggests that factors specific to the perinatal hepatic environment are important for disease propagation. Hematopoietic stem and progenitor cells (HSPCs) reside in the fetal liver and are known to serve as central hubs of inflammation. We hypothesized that HSPCs are critical for the propagation of perinatal liver injury (PLI).

methodsNewborn BALB/c mice were injected with rhesus rotavirus (RRV) to induce PLI or with PBS as control. Livers were compared using histology and flow cytometry. To determine the effects of HSPCs on PLI, RRV-infected neonatal mice were administered anti-CD47 and anti-CD117 to deplete HSPCs.

resultsPLI significantly increased the number of common myeloid progenitors and the number of CD34

conclusionsHSPCs expand as a result of RRV infection and propagate PLI. Targeting of HSPCs may be useful in preventing and treating neonatal inflammatory diseases of the liver such as BA.

Indexed as

biliary atresiahematopoietic stem and progenitor cellsmyeloid progenitor cellsperinatal liver injury

Identifiers

PMID36615137
PMCPMC9821039
OpenAlexW4313473143

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.