Evidence map›Paper›PMID 36614816›Full record

ReviewJournal of clinical medicine2022

Non-Adherence to Anti-Osteoporosis Medication: Factors Influencing and Strategies to Overcome It. A Narrative Review.

Giulia Rita Agata Mangano, Marianna Avola, Chiara Blatti, Alessia Caldaci, Marco Sapienza, Rita Chiaramonte, Michele Vecchio, Vito Pavone, Gianluca Testa

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Observational
  3. Postoperative osteoporosis therapy and risk of re-fracture in elderly patients with hip fractures: a multicenter retrospective cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  4. Article
  5. Article
  6. Adherence to secondary fracture prevention is associated with reduced risk of subsequent fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  7. Review
  8. Article
  9. Lactylation-related geneFrontiers in immunology · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Giulia Rita Agata ManganoDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology, University Hospital Policlinico-San Marco, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-6019-4167
Marianna AvolaDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology, University Hospital Policlinico-San Marco, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-3177-8731
Chiara BlattiDepartment of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, University Hospital Policlinico-San Marco, University of Catania, 95123 Catania, Italy.
Alessia CaldaciDepartment of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, University Hospital Policlinico-San Marco, University of Catania, 95123 Catania, Italy.
Marco SapienzaDepartment of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, University Hospital Policlinico-San Marco, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-8311-9132
Rita ChiaramonteDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology, University Hospital Policlinico-San Marco, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-1256-7605
Michele VecchioDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology, University Hospital Policlinico-San Marco, University of Catania, 95123 Catania, Italy.
Vito PavoneDepartment of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, University Hospital Policlinico-San Marco, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-5664-8066
Gianluca TestaDepartment of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, University Hospital Policlinico-San Marco, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-5246-9714
University of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the reasons for inadequate adherence to osteoporosis therapy and to describe the strategies for improving adherence to and persistence with regular medications, we conducted a review of the literature. The primary outcome of the study was the determination of the factors adverse to the onset and maintenance of anti-osteoporosis therapies. Secondly, we focused on studies whose efforts led to finding different strategies to improve adherence and persistence. We identified a total of 26 articles. The most recurrent and significant factors identified were aging, polypharmacy, and smoking habits. Different strategies to guide patients in their osteoporosis care have been identified, such as monitoring and follow-up via telephone calls, email, and promotional meetings, and proactive care interventions such as medication monitoring, post-fracture care programs, and decision aids. Changes in the drugs regimen and dispensation are strategies tried to lead to better adherence and persistence, but also improved satisfaction of patients undergoing anti-osteoporosis treatment. Patient involvement is an important factor to increase medication persistence while using a flexible drugs regimen.

Indexed as

adherence medicationsdrug regimeneducational meetingelderlyfracturesfrailtymedication monitoringosteoporosispost-fracture carepostmenopausal

Identifiers

PMID36614816
PMCPMC9821321
OpenAlexW4313467113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.