Evidence map›Paper›PMID 36614815›Full record

ArticleJournal of clinical medicine2022

Impact of Chronic Kidney Disease on Corneal Neuroimmune Features in Type 2 Diabetes.

Kofi Asiedu, Maria Markoulli, Shyam Sunder Tummanapalli, Jeremy Chung Bo Chiang, Sultan Alotaibi, Leiao Leon Wang, Roshan Dhanapalaratnam, Natalie Kwai, Ann Poynten, Arun V Krishnan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Assessing corneal dendritic cells in glucose dysregulation small-fibre neuropathy.Journal of the peripheral nervous system : JPNS · 2024
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Kofi AsieduSchool of Optometry & Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.
Maria MarkoulliSchool of Optometry & Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.
Shyam Sunder TummanapalliSchool of Optometry & Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.
Jeremy Chung Bo ChiangSchool of Optometry & Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-6133-7411
Sultan AlotaibiSchool of Optometry & Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.
Leiao Leon WangSchool of Clinical Medicine, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-0273-1814
Roshan DhanapalaratnamSchool of Clinical Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Natalie KwaiSchool of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia.
Ann PoyntenDepartment of Endocrinology, Prince of Wales Hospital, Sydney, NSW 2031, Australia.
Arun V KrishnanSchool of Clinical Medicine, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0001-8883-8825
UNSW Sydney · AUPrince of Wales Hospital · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: To determine the impact of chronic kidney disease on corneal nerve measures and dendritic cell counts in type 2 diabetes. Methods: In vivo corneal confocal microscopy images were used to estimate corneal nerve parameters and compared in people with type 2 diabetes with chronic kidney disease (T2DM-CKD) (n = 29) and those with type 2 diabetes without chronic kidney disease (T2DM-no CKD) (n = 29), along with 30 healthy controls. Corneal dendritic cell densities were compared between people with T2DM-CKD and those with T2DM-no CKD. The groups were matched for neuropathy status. Results: There was a significant difference in corneal nerve fiber density (p < 0.01) and corneal nerve fiber length (p = 0.04) between T2DM-CKD and T2DM-no CKD groups. The two diabetes groups had reduced corneal nerve parameters compared to healthy controls (all parameters: p < 0.01). Immature central dendritic cell density was significantly higher in the T2DM-CKD group compared to the T2DM-no CKD group ((7.0 (3.8−12.8) and 3.5 (1.4−13.4) cells/mm2, respectively, p < 0.05). Likewise, central mature dendritic cell density was significantly higher in the T2DM-CKD group compared to the T2DM-no CKD group (0.8 (0.4−2.2) and 0.4 (0.6−1.1) cells/mm2, respectively, p = 0.02). Additionally, total central dendritic cell density was increased in the T2DM-CKD group compared to T2DM-no CKD group (10.4 (4.3−16.1) and 3.9 (2.1−21.0) cells/mm2, respectively, p = 0.03). Conclusion: The study showed that central corneal dendritic cell density is increased in T2DM-CKD compared to T2DM-no CKD, with groups matched for peripheral neuropathy severity. This is accompanied by a loss of central corneal nerve fibers. The findings raise the possibility of additional local factors exacerbating central corneal nerve injury in people with diabetic chronic kidney disease.

Indexed as

chronic kidney diseasecorneal nervesdendritic cellsdiabetesneuroinflammation

Identifiers

PMID36614815
PMCPMC9820846
OpenAlexW4313467108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.