ArticleMaterials (Basel, Switzerland)2022
Macrophage Polarization Related to Biomimetic Calcium Phosphate Coatings: A Preliminary Study.
Article in Materials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Intracellular Calcium as a Regulator of Polarization and Target Reprogramming of Macrophages.International journal of molecular sciences · 2025Review
- Osteoinductive micro-nano guided bone regeneration membrane for in situ bone defect repair.Stem cell research & therapy · 2024Article
- Calcium phosphate coating enhances osteointegration of melt electrowritten scaffold by regulating macrophage polarization.Journal of nanobiotechnology · 2024Article
- Mg, Zn Substituted Calcium Phosphates-Thermodynamic Modeling, Biomimetic Synthesis in the Presence of Low-Weight Amino Acids and High Temperature Properties.Materials (Basel, Switzerland) · 2023Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Biomimetic calcium phosphate (BioCaP) coatings were used to deliver bone morphogenetic protein 2 (BMP2), and enhance osteogenesis. However, the mechanism for BioCaP coatings interacting with the immune response during bone regeneration remains unclear. In this preliminary study, the effect of BioCaP coatings on macrophage polarization without (BioCaP group) or with BMP2 (BioCaP+Inc.BMP2 group) was investigated. RAW 264.7 cells were cultured on the rough and platelike surfaces of coatings in BioCaP and BioCaP+Inc.BMP2 groups, while cultured on smooth surfaces in the group without material for 5 days. The BioCaP coatings per se modulated the switch of M1 to M2 phenotype from day 3, which promoted the expressions of Arg1 and CD 206 but reduced the expression of TNF-α compared with No material group. To detect the microenvironmental changes, the concentrations of calcium ion (Ca
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Registered trials
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