Evidence map›Paper›PMID 36614281›Full record

Trial reportInternational journal of molecular sciences2023

Polyphenol-Rich Beverage Consumption Affecting Parameters of the Lipid Metabolism in Healthy Subjects.

Celina Rahn, Tamara Bakuradze, Simone Stegmüller, Jens Galan, Sonja Niesen, Peter Winterhalter, Elke Richling

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Impact of a Chokeberry (Nutrients · 2025
    Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Celina RahnDivision of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Erwin-Schrödinger-Straße 52, D-67663 Kaiserslautern, Germany.
Tamara BakuradzeDivision of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Erwin-Schrödinger-Straße 52, D-67663 Kaiserslautern, Germany.
Simone StegmüllerDivision of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Erwin-Schrödinger-Straße 52, D-67663 Kaiserslautern, Germany.
Jens GalanMedical Institute, Hochgewanne 19, D-67269 Grünstadt, Germany.
Sonja NiesenInstitute of Food Chemistry, Technische Universität Braunschweig, Schleinitzstraße 20, D-38106 Braunschweig, Germany.
Peter WinterhalterInstitute of Food Chemistry, Technische Universität Braunschweig, Schleinitzstraße 20, D-38106 Braunschweig, Germany.ORCID 0000-0003-3417-6023
Elke RichlingDivision of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Erwin-Schrödinger-Straße 52, D-67663 Kaiserslautern, Germany.ORCID 0000-0001-5746-8032
University of Kaiserslautern · DETechnische Universität Braunschweig · DE

Funding

Industrial Collective Research (IGF) of the German Ministry of Economics and Climate Action (BMWK) AiF 20227N
6 · The paper itself

Abstract

Polyphenols are a diverse and widely distributed class of secondary metabolites, which possess numerous beneficial properties including a modulation of glucose and lipid metabolism. This placebo-controlled human intervention study was performed to explore effects of polyphenol-rich beverage (PRB) uptake on lipid metabolism, as well as DNA integrity. In this case, 36 healthy men were randomly divided to consume either 750 mL of a PRB (containing 51% chokeberry, cranberry, and pomegranate) or a placebo drink daily for eight weeks. Only PRB consumption was found to decrease fat and protein intakes significantly compared to the preceding one-week washout period. During the intervention with PRB an increased fat-free mass was shown after four weeks, whereas a significant elevation in body weight and leptin was observed in placebo group. Blood lipids were not significantly altered after PRB consumption, while triglyceride levels increased after placebo drink intake. In platelets, a significant inhibition of phosphodiesterase (PDE) activity was observed, more pronounced in test group. Consuming the PRB decreased total DNA strand breaks in whole blood as well as H

Indexed as

BeveragesLipid MetabolismPhotiniaPolyphenolsPomegranateVaccinium macrocarponDouble-Blind MethodHealthy VolunteersHumansHydrogen PeroxideMaleHydrogen PeroxidePolyphenolsDNA integrityhuman intervention studylipid metabolismphosphodiesterase activitypolyphenol-rich beverage

Identifiers

PMID36614281
PMCPMC9821765
OpenAlexW4313584431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.