Evidence map›Paper›PMID 36614262›Full record

ArticleInternational journal of molecular sciences2023

Pinostrobin Suppresses the α-Melanocyte-Stimulating Hormone-Induced Melanogenic Signaling Pathway.

Athapaththu Mudiyanselage Gihan Kavinda Athapaththu, Sobarathne Senel Sanjaya, Kyoung Tae Lee, Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Yung Hyun Choi, Sung-Pyo Hur, Gi-Young Kim

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. [Pinostrobin targets the PI3K/AKT/CCLNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  5. The Contribution of Human Antimicrobial Peptides to Fungi.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Phenolic acids inJournal of ginseng research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Athapaththu Mudiyanselage Gihan Kavinda AthapaththuDepartment of Marine Life Science, Jeju National University, Jeju 63243, Republic of Korea.ORCID 0000-0002-4332-4254
Sobarathne Senel SanjayaDepartment of Marine Life Science, Jeju National University, Jeju 63243, Republic of Korea.
Kyoung Tae LeeForest Bioresources Department, Forest Microbiology Division, National Institute of Forest Science, Suwon 16631, Republic of Korea.
Wisurumuni Arachchilage Hasitha Maduranga KarunarathneDepartment of Marine Life Science, Jeju National University, Jeju 63243, Republic of Korea.ORCID 0000-0001-6398-8552
Yung Hyun ChoiDepartment of Biochemistry, College of Korean Medicine, Dong-Eui University, Busan 47227, Republic of Korea.ORCID 0000-0002-1454-3124
Sung-Pyo HurDepartment of Marine Life Science, Jeju National University, Jeju 63243, Republic of Korea.
Gi-Young KimDepartment of Marine Life Science, Jeju National University, Jeju 63243, Republic of Korea.ORCID 0000-0002-6878-0790
Jeju National University · KRDong-Eui University · KRKorea Forest Service · KRUniversity of Ruhuna · LK

Funding

Jeju National University 2022 scientific promotion program
6 · The paper itself

Abstract

Pinostrobin is a dietary flavonoid found in several plants that possesses pharmacological properties, such as anti-cancer, anti-virus, antioxidant, anti-ulcer, and anti-aromatase effects. However, it is unclear if pinostrobin exerts anti-melanogenic properties and, if so, what the underlying molecular mechanisms comprise. Therefore, we, in this study, investigated whether pinostrobin inhibits melanin biosynthesis in vitro and in vivo, as well as the potential associated mechanism. Pinostrobin reduced mushroom tyrosinase activity in vitro in a concentration-dependent manner, with an IC

Indexed as

MelaninsMelanoma, Experimentalalpha-MSHAnimalsCell Line, TumorFlavanonesMicrophthalmia-Associated Transcription FactorMolecular Docking SimulationMonophenol MonooxygenaseSignal TransductionZebrafishalpha-MSHFlavanonesMelaninsMicrophthalmia-Associated Transcription FactorMonophenol Monooxygenasepinostrobinmelanogenesispinostrobintyrosinaseα-MSH

Identifiers

PMID36614262
PMCPMC9821324
OpenAlexW4313516646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.