Evidence map›Paper›PMID 36614212›Full record

ArticleInternational journal of molecular sciences2023

High Acetate Concentration Protects Intestinal Barrier and Exerts Anti-Inflammatory Effects in Organoid-Derived Epithelial Monolayer Cultures from Patients with Ulcerative Colitis.

Sara Deleu, Kaline Arnauts, Lowie Deprez, Kathleen Machiels, Marc Ferrante, Geert R B Huys, Johan M Thevelein, Jeroen Raes, Séverine Vermeire

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Pooled it
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  14. Pterostilbene-mediated microbiota shifts: Implications and opportunities.Journal of traditional and complementary medicine · 2026
    Review
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  16. Review
  17. Article
  18. The role of theFrontiers in microbiology · 2026
    Review
  19. mBio · 2025
    Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sara DeleuDepartment of Chronic Diseases, Metabolism & Ageing (CHROMETA), KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-8596-2783
Kaline ArnautsDepartment of Chronic Diseases, Metabolism & Ageing (CHROMETA), KU Leuven, 3000 Leuven, Belgium.
Lowie DeprezDepartment of Chronic Diseases, Metabolism & Ageing (CHROMETA), KU Leuven, 3000 Leuven, Belgium.
Kathleen MachielsDepartment of Chronic Diseases, Metabolism & Ageing (CHROMETA), KU Leuven, 3000 Leuven, Belgium.
Marc FerranteDepartment of Chronic Diseases, Metabolism & Ageing (CHROMETA), KU Leuven, 3000 Leuven, Belgium.
Geert R B HuysCenter for Microbiology, VIB, 3000 Leuven, Belgium.ORCID 0000-0002-7092-4837
Johan M TheveleinCenter for Microbiology, VIB, 3000 Leuven, Belgium.ORCID 0000-0002-2626-0180
Jeroen RaesCenter for Microbiology, VIB, 3000 Leuven, Belgium.
Séverine VermeireDepartment of Chronic Diseases, Metabolism & Ageing (CHROMETA), KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-9942-3019
KU Leuven · BERega Institute for Medical Research · BEVIB-KU Leuven Center for Microbiology · BE

Funding

European Research Council 694679Grand Challenges Program of VIB VR 2021 1712 DOC. 1492/4
6 · The paper itself

Abstract

Short-chain fatty acids as well as their bacterial producers are of increasing interest in inflammatory bowel diseases. Although less studied compared to butyrate, acetate might also be of interest as it may be less toxic to epithelial cells, stimulate butyrate-producing bacteria by cross-feeding, and have anti-inflammatory and barrier-protective properties. Moreover, one of the causative factors of the probiotic potency of

Indexed as

ColitisColitis, UlcerativeAcetatesButyratesHumansInflammationIntestinal MucosaOrganoidsAcetatesButyratesacetateIBDinflammatory bowel diseaseprebioticsprobioticsSCFAshort chain fatty acidsulcerative colitis

Identifiers

PMID36614212
PMCPMC9821118
OpenAlexW4313471508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.