Evidence map›Paper›PMID 36614200›Full record

ArticleInternational journal of molecular sciences2023

Expression and Function of StAR in Cancerous and Non-Cancerous Human and Mouse Breast Tissues: New Insights into Diagnosis and Treatment of Hormone-Sensitive Breast Cancer.

Pulak R Manna, Sabarish Ramachandran, Jangampalli Adi Pradeepkiran, Deborah Molehin, Isabel Castro-Piedras, Kevin Pruitt, Vadivel Ganapathy, P Hemachandra Reddy

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Harnessing the Role ofInternational journal of molecular sciences · 2025
    Article
  4. Review
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  6. Article
  7. Enzymes Dysregulation in Cancer: From Diagnosis to Therapeutical Approaches.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Pulak R MannaDepartment of Internal Medicine, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430, USA.
Sabarish RamachandranDepartment of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430, USA.
Jangampalli Adi PradeepkiranDepartment of Internal Medicine, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430, USA.ORCID 0000-0003-4678-6443
Deborah MolehinDepartment of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430, USA.
Isabel Castro-PiedrasDepartment of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430, USA.ORCID 0000-0001-5479-123X
Kevin PruittDepartment of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430, USA.
Vadivel GanapathyDepartment of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430, USA.
P Hemachandra ReddyDepartment of Internal Medicine, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430, USA.ORCID 0000-0002-9560-9948
Texas Tech University · US

Funding

Cancer Prevention Research Institute of Texas and Welch Endowed Chair in Biochemistry RR140008 and B10028NIH HHS CA155223, R01AG042178, R01AG47812, R01NS105473, AG060767, AG069333, and AG066347
6 · The paper itself

Abstract

Breast cancer (BC) is primarily triggered by estrogens, especially 17β-estradiol (E2), which are synthesized by the aromatase enzyme. While all steroid hormones are derived from cholesterol, the rate-limiting step in steroid biosynthesis is mediated by the steroidogenic acute regulatory (StAR) protein. Herein, we demonstrate that

Indexed as

Breast NeoplasmsMammary Neoplasms, AnimalTriple Negative Breast NeoplasmsAnimalsAromataseEstradiolFemaleHumansMiceMice, TransgenicRNA, MessengerAromataseEstradiolRNA, MessengeraromataseBC therapybreast cancerestrogen/E2HDAC inhibitorshormone-sensitive BCmouse models of BCsStAR

Identifiers

PMID36614200
PMCPMC9820903
OpenAlexW4313471864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.