Evidence map›Paper›PMID 36614162›Full record

ArticleInternational journal of molecular sciences2022

Splice-Site Variants in the Gene Encoding GABA-A Receptor Delta Subunit Are Associated with Amphetamine Use in Patients under Methadone Maintenance Treatment.

Yen-Feng Lin, Wen-Hai Chou, Tung-Hsia Liu, Chiu-Ping Fang, Hsiang-Wei Kuo, Po-Hsiu Kuo, Shih-Jen Tsai, Sheng-Chang Wang, Ren-Hua Chung, Hsiao-Hui Tsou and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 42 citations in OpenAlex.

  1. Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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  10. Single-cell and spatial transcriptomics reveal mTOR-driven cellular fate of spindle cells and immune evasion in classic Kaposi's sarcoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
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  15. Exercise and CD8Journal of molecular medicine (Berlin, Germany) · 2026
    Review
  16. Crosstalk between protein lipidation and ubiquitination in tumor biology.Apoptosis : an international journal on programmed cell death · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Yen-Feng LinCenter for Neuropsychiatric Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan.ORCID 0000-0003-3017-6026
Wen-Hai ChouCenter for Neuropsychiatric Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan.
Tung-Hsia LiuCenter for Neuropsychiatric Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan.
Chiu-Ping FangCenter for Neuropsychiatric Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan.
Hsiang-Wei KuoCenter for Neuropsychiatric Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan.
Po-Hsiu KuoDepartment of Public Health & Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 100, Taiwan.ORCID 0000-0003-0365-3587
Shih-Jen TsaiDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Sheng-Chang WangCenter for Neuropsychiatric Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan.
Ren-Hua ChungInstitute of Population Health Sciences, National Health Research Institutes, Miaoli County 350, Taiwan.
Hsiao-Hui TsouInstitute of Population Health Sciences, National Health Research Institutes, Miaoli County 350, Taiwan.ORCID 0000-0001-6773-4111
Andrew C H ChenDepartment of Psychiatry, Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York, NY 11004, USA.ORCID 0000-0003-1376-8505
Yu-Li LiuCenter for Neuropsychiatric Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan.
National Health Research Institutes · TWNational Taiwan University · TWNorthwell Health · USTaipei Veterans General Hospital · TW

Funding

Ministry of Science and Technology MOST 106-2320-B-400-012National Health Research Institutes NP-111-SP-01, NP-111-PP-03, NP-111-PP-08, NP-111-PP-09, and PH-111-PP-02National Research Program for Genomic Medicine NSC 100-3112-B-400-015
6 · The paper itself

Abstract

Chronic opioid use disorder patients often also use other substances such as amphetamines. The gene-based analysis method was applied in the genomic database obtained from our previous study with 343 methadone maintenance treatment (MMT) patients. We found that the gene encoding gamma-aminobutyric acid type A receptors (GABA-A receptor) delta subunit isoforms (

Indexed as

AmphetamineOpioid-Related DisordersReceptors, GABA-AGenotypeHumansMethadoneRNA Splice SitesAmphetamineGABRD protein, humanMethadoneReceptors, GABA-ARNA Splice Sitesamphetamine useGABRDmethadone maintenance treatmentpolysubstance abusepsychostimulant

Identifiers

PMID36614162
PMCPMC9820820
OpenAlexW4313392040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.