Evidence map›Paper›PMID 36614155›Full record

ReviewInternational journal of molecular sciences2022

The Management of Ocular Surface Squamous Neoplasia (OSSN).

Clarice H Y Yeoh, Jerome J R Lee, Blanche X H Lim, Gangadhara Sundar, Jodhbir S Mehta, Anita S Y Chan, Dawn K A Lim, Stephanie L Watson, Santosh G Honavar, Ray Manotosh and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  11. Role of epigenetics in corneal health and disease.Progress in retinal and eye research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Clarice H Y YeohYong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.ORCID 0000-0001-8158-755X
Jerome J R LeeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 639798, Singapore.
Blanche X H LimYong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Gangadhara SundarYong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Jodhbir S MehtaDuke-NUS Graduate Medical School, Singapore 169857, Singapore.
Anita S Y ChanDuke-NUS Graduate Medical School, Singapore 169857, Singapore.
Dawn K A LimYong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Stephanie L WatsonSave Sight Institute, Discipline of Ophthalmology, Sydney Medical School, The University of Sydney, Sydney, NSW 2000, Australia.ORCID 0000-0001-6699-1765
Santosh G HonavarCenter for Sight, Hyderabad 500034, India.
Ray ManotoshYong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Chris H L LimYong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.ORCID 0000-0003-2219-3184
National University of Singapore · SGCentre for Sight · INNanyang Technological University · SGSingapore General Hospital · SGSingapore National Eye Center · SGThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rise of primary topical monotherapy with chemotherapeutic drugs and immunomodulatory agents represents an increasing recognition of the medical management of ocular surface squamous neoplasia (OSSN), which may replace surgery as the standard of care in the future. Currently, there is no consensus regarding the best way to manage OSSN with no existing guidelines to date. This paper seeks to evaluate evidence surrounding available treatment modalities and proposes an approach to management. The approach will guide ophthalmologists in selecting the most appropriate treatment regime based on patient and disease factors to minimize treatment related morbidity and improve OSSN control. Further work can be done to validate this algorithm and to develop formal guidelines to direct the management of OSSN.

Indexed as

Antineoplastic AgentsCarcinoma, Squamous CellConjunctival NeoplasmsHumansInterferon alpha-2Surveys and QuestionnairesAntineoplastic AgentsInterferon alpha-25-fluorouracil (5-FU)adjunctsinterferon alfa (INFα)managementmitomycin C (MMC)ocular surface squamous neoplasiasurgical excisiontopical chemotherapy

Identifiers

PMID36614155
PMCPMC9821412
OpenAlexW4313471758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.