Evidence map›Paper›PMID 36614143›Full record

ArticleInternational journal of molecular sciences2022

Phosphodiesterase 5a Signalling in Skeletal Muscle Pathophysiology.

Valeria De Arcangelis, Luciana De Angelis, Federica Barbagallo, Federica Campolo, Ana Gabriela de Oliveira do Rego, Manuela Pellegrini, Fabio Naro, Mauro Giorgi, Lucia Monaco

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. In the Brain of Phosphodiesterases: Potential Therapeutic Targets for Schizophrenia.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Valeria De ArcangelisNeurology Unit Department of Neuroscience, Fondazione Policlinico Univeristario Agostino Gemelli IRCC, 00168 Rome, Italy.
Luciana De AngelisDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University, 00161 Rome, Italy.
Federica BarbagalloFaculty of Medicine and Surgery, "Kore" University of Enna, 94100 Enna, Italy.
Federica CampoloDepartment of Experimental Medicine, Sapienza University, 00161 Rome, Italy.ORCID 0000-0002-9290-874X
Ana Gabriela de Oliveira do RegoDepartment of Biology and Biotechnology "C. Darwin", Sapienza University, 00185 Rome, Italy.
Manuela PellegriniInstitute of Biochemistry and Cell Biology, IBBC-CNR, 00015 Rome, Italy.ORCID 0000-0001-6387-5187
Fabio NaroDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University, 00161 Rome, Italy.ORCID 0000-0003-0572-5900
Mauro GiorgiDepartment of Biology and Biotechnology "C. Darwin", Sapienza University, 00185 Rome, Italy.
Lucia MonacoDepartment of Physiology and Pharmacology, Sapienza University, 00185 Rome, Italy.
Sapienza University of Rome · ITAgostino Gemelli University Polyclinic · ITInstitute of Cell Biology and Neurobiology · ITUniversità degli Studi di Enna Kore · IT

Funding

Sapienza University of Rome Grant 00031519Sapienza University of Rome Grant RM120172A3B45898Sapienza University of Rome Grant RM12117A5C8B2B1ASapienza University of Rome Grant RP120172A796BA45
6 · The paper itself

Abstract

Phosphodiesterase 5A (PDE5A) is involved in cGMP hydrolysis, regulating many physiological processes. Increased activity of PDE5A has been found in several pathological conditions, and the pharmacological inhibition of PDE5 has been demonstrated to have several therapeutic applications. We have identified the presence of three different

Indexed as

3',5'-Cyclic-GMP PhosphodiesterasesSignal TransductionCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 5Muscle, Skeletal3',5'-Cyclic-GMP PhosphodiesterasesCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 5atrophymuscular disordersPde5a isoformsphosphodiesterases

Identifiers

PMID36614143
PMCPMC9820699
OpenAlexW4313391909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.