Evidence map›Paper›PMID 36614109›Full record

ArticleInternational journal of molecular sciences2022

Drug Repurposing against KRAS Mutant G12C: A Machine Learning, Molecular Docking, and Molecular Dynamics Study.

Tarapong Srisongkram, Natthida Weerapreeyakul

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. KRASAVA-An Expert System for Virtual Screening of KRAS G12D Inhibitors.International journal of molecular sciences · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Prediction of Drug Targets based on In Vitro Activity Profiles Toward Drug Repurposing for Rare Diseases.IEEE International Conference on Bioinformatics and Biomedicine workshops. IEEE International Conference on Bioinformatics and Biomedicine · 2023
    Article
  17. Targeting KRAS in Colorectal Cancer: A Bench to Bedside Review.International journal of molecular sciences · 2023
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tarapong SrisongkramDivision of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0001-8512-5379
Natthida WeerapreeyakulDivision of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0002-0810-8425

Funding

Research Grant for New Scholar from the Office of the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation, Thailand RGNS65-052The Fundamental Fund of Khon Kaen University, has receive funding support from the National Science, Research and Innovation Fund (NSRF
6 · The paper itself

Abstract

The Kirsten rat sarcoma viral G12C (KRAS

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsAfatinibArtificial IntelligenceDrug RepositioningHumansMachine LearningMolecular Docking SimulationMolecular Dynamics SimulationMutationProto-Oncogene Proteins p21(ras)AfatinibKRAS protein, humanProto-Oncogene Proteins p21(ras)adagrasibafatinibartificial intelligencecovalent drugsdrug repositioningdrug repurposingextreme gradient boostingNSCLCQSARsotorasibXGBoost

Identifiers

PMID36614109
PMCPMC9821013

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.