Evidence map›Paper›PMID 36614056›Full record

ArticleInternational journal of molecular sciences2022

Targeting Lysosomes in Colorectal Cancer: Exploring the Anticancer Activity of a New Benzo[

João C C Ferreira, Sara Granja, Ana F Almeida, Fátima Baltazar, M Sameiro T Gonçalves, Ana Preto, Maria João Sousa

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. "Doing everything we can": parents' strategies for managing chemotherapy-related symptoms in children with leukemia at home.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  9. Progress of Section "Biochemistry" in 2022.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

João C C FerreiraCentre of Molecular and Environmental Biology (CBMA), Department of Biology, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.
Sara GranjaDepartment of Pathological, Cytological and Thanatological Anatomy, School of Health, Polytechnic Institute of Porto, 4200-072 Porto, Portugal.
Ana F AlmeidaCentre of Molecular and Environmental Biology (CBMA), Department of Biology, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0001-6663-6851
Fátima BaltazarLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.ORCID 0000-0002-1770-4544
M Sameiro T GonçalvesCentre of Chemistry, Department of Chemistry, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0003-2048-1190
Ana PretoCentre of Molecular and Environmental Biology (CBMA), Department of Biology, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0002-7302-0630
Maria João SousaCentre of Molecular and Environmental Biology (CBMA), Department of Biology, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0001-9424-4150
University of Minho · PTPolytechnic Institute of Porto · PT

Funding

Fundação para a Ciência e Tecnologia PTDC/QUIQIN/28662/2017.Fundação para a Ciência e Tecnologia PTNMR, Bruker Avance III 400-Univ. MinhoFundação para a Ciência e Tecnologia SFRH/BD/133207/2017; COVID/BD/151978/2021Fundação para a Ciência e Tecnologia UID/BIA/04050/2020, UID/QUI/00686/2016 and UID/ QUI/0686/2021
6 · The paper itself

Abstract

Colorectal cancer (CRC) has been ranked as one of the cancer types with a higher incidence and one of the most mortal. There are limited therapies available for CRC, which urges the finding of intracellular targets and the discovery of new drugs for innovative therapeutic approaches. In addition to the limited number of effective anticancer agents approved for use in humans, CRC resistance and secondary effects stemming from classical chemotherapy remain a major clinical problem, reinforcing the need for the development of novel drugs. In the recent years, the phenoxazines derivatives, Nile Blue analogues, have been shown to possess anticancer activity, which has created interest in exploring the potential of these compounds as anticancer drugs. In this context, we have synthetized and evaluated the anticancer activity of different benzo[

Indexed as

Antineoplastic AgentsColorectal NeoplasmsLysosomesOxazinesAnimalsApoptosisCell Line, TumorChick EmbryoAntineoplastic AgentsOxazinesphenoxazineanticancer drugbenzo[a]phenoxazinecolorectal cancerlysosome membrane permeabilizationNile Blue analogue

Identifiers

PMID36614056
PMCPMC9820173
OpenAlexW4313409763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.